Progress in Chemical Toxicology (eBook)

Front Cover 1
Progress in Chemical Toxicology 4
Copyright Page 5
Table of Contents 10
CONTRIBUTORS 6
PREFACE 8
CONTENTS OF OTHER VOLUMES 14
CHAPTER 1. ALIPHATIC ALCOHOLS 18
I. Introduction 18
II. "Endogenous" Alcohols 19
III. Distribution of Absorbed Alcohol 23
IV. Fate of Absorbed Alcohol 31
V. Pharmacological and Physiological Effects 47
VI. Post-mortem Changes in Cadaver Blood 63
VII. Analytical Methods for Body Alcohol 63
VIII. Investigations of the Accuracy of Analytical Methods 66
IX. Other Aliphatic Alcohols 72
References 75
CHAPTER 2. VOLATILE TOXIC COMPOUNDS 80
I. Introduction 80
II. Halogenated Aliphatic Compounds 83
III. Aromatic Hydrocarbons 99
IV. Volatile Acidic Compounds 104
References 111
CHAPTER 3. METHODS FOR THE DETERMINATION OF CARBON MONOXIDE 116
I. Introduction 116
II. Preparation of Carbon Monoxide Standard Mixtures 117
III. Collection of Air and Breath Samples 118
IV. Analysis of Air and Breath Samples 119
V. Analysis of Blood Samples 126
References 136
CHAPTER 4. APPLICATION OF GAS CHROMATOGRAPHY TO TOXICOLOGY 138
I. Introduction 138
II. Detectors 141
III. Columns 144
IV. Qualitative Techniques 147
V. Analytical Procedures 178
References 230
CHAPTER 5. DEVELOPMENTS IN SPECTROGRAPHY: SPECTROCHEMICAL METHODS 236
I. Introduction 237
II. Equipment and Materials 237
III. Procedures 244
References 261
CHAPTER 6. DETECTION OF RADIONUCLIDES OF BIOLOGICAL INTEREST IN HUMAN BONES AND TISSUES 262
I. Introduction 262
II. Chemical Processing and Separation of Radionuclides in Biological Material 271
III. Chemical Separation and Determination of Radionuclides 275
IV. Radiochemical Determination of Strontium-90 and Strontium-89 276
V. Radiochemical Determination of Cesium-137 288
VI. Radiochemical Determination of Iodine-131 296
VII. Radiochemical Determination of Radium-226 297
VIII. Thorium (Thorotrast) 304
IX. Radiochemical Determination of Uranium 304
X. Radiochemical Determination of Plutonium-239 . 307
XI. Instrumentation 310
XII. Results of Measurements 310
References 318
CHAPTER 7. COMBINED ACTION OF DRUGS WITH TOXICOLOGICAL IMPLICATIONS—PART I 322
I. Introduction 322
II. Factors Affecting Duration of Drug Action 327
III. Decreased Duration of Combined Drug Action 329
IV. Increased Duration of Combined Drug Action 330
References 374
CHAPTER 8. POISON RESIDUES IN HUMAN TISSUES 380
I. Introduction 380
II. Salicylates 383
III. Barbiturates 383
IV. Chloral Hydrate 384
V. Paraldehyde 384
VI. Cyanide 386
VII. Tranquilizers 396
VIII. Boric Acid 396
IX. Metallic Poisons 396
References 403
AUTHOR INDEX 404
SUBJECT INDEX 420