Progress in Chemical Toxicology (eBook)

Front Cover 1
Progress in Chemical Toxicology 4
Copyright Page 5
Table of Contents 10
Contributors 6
Preface 8
Chapter 1. The Absorption, Distribution, and Excretion of Poisons and Their Metabolites 12
I. Gas and Vapors (Poisons through Inhalation) 13
II. Volatile Liquids (Steam Volatile) 22
III. Drugs Extractable by Organic Solvents from Aqueous Acid Solution 40
IV. Drugs Extractable by Organic Solvents from Aqueous Alkaline Solutions 72
V. Metallic Poisons 152
REFERENCES 177
Chapter 2. Detection of Volatile Organic Compounds and Toxic Gases in Humans by Rapid Infrared Techniques 194
I. Introduction 194
II . Infrared Analysis of Expired Breath 200
III. Infrared Analysis of Solvent Extractions of Body Fluids 220
IV. Infrared Analysis of Solvent Extractions of Tissues 223
V. Identification and Interpretation of Infrared Spectra 225
REFERENCES 231
Chapter 3. An Approach to the Analysis of Biological Specimens for Basic Drugs 232
I. Introduction 232
II. Analytical Procedure 232
REFERENCES 249
Chapter 4. Rapid Methods of Toxicological Analysis by Ion-Exchange Paper Chromatography and lonophoresis 250
I. The Use of Modified Cellulose Ion-Exchange Sheets in Toxicological Analysis 251
II. Rapid Separation of Drugs by Chromatography at Elevated Temperatures on Ester-Impregnated Paper 279
III. Rapid Identification of Mixtures of Barbiturates by Heating with Concentrated Sulfuric Acid 286
ACKNOWLEDGMENTS 291
REFERENCES 291
Chapter 5. Developments in Spectrography: Sample Preparation 294
I. Introduction 295
II. Destruction of Organic Matter 295
III. Concentration, Isolation, Enrichment 308
ACKNOWLEDGMENTS 327
REFERENCES 327
Chapter 6. Thin Layer Chromatography Application in Toxicology 332
I. Introduction 332
II. Adsorbents 333
III. Preparation of Plates 338
IV. Coating the Plates 338
V. Activation of Layers 340
VI. Application of Samples 341
VII. Development of Plates 343
VIII. Solvents 346
IX. Qualitative Estimation 347
X. Documentation of Results 347
XI. Elution of Drugs 348
XII. Specific Examples of Separation of Drugs 348
REFERENCES 392
AUTHOR INDEX 394
SUBJECT INDEX 411