Drug Design (eBook)

Front Cover 1
Drug Design 4
Copyright Page 5
Table of Contents 6
Preface 10
Contents of Other Volumes 12
Chapter 1. The Design of Artificial Blood Substitutes 18
I. Introduction 18
II. Constituents 21
III. Formulation of Artificial Blood Substitutes 48
IV. Preparation of Perfluorochemical-Type Artificial Blood Substitutes 49
V. Testing Procedures 54
VI. Biological Considerations 65
VII. Potential and Summary 70
ACKNOWLEDGMENTS 72
References 72
Chapter 2. Insect Pheromones as a Basis for the Development of More Effective Selective Pest Control Agents 76
I. Introduction 77
II. Terminology 78
III. Identification of Pheromones 81
IV. Sex Pheromones of Lepidoptera 84
V. Pheromones and Food Attractants of Termites 96
VI. Ant Trail Pheromones and Related Semiochemicals 105
VII. Application of Pheromones and Their Analogs in Pest Control 111
VIII. Prospects for Designing New Compounds with Pheromonal Activities (Parapheromones) 119
References 122
Chapter 3. The Design of Auxin-Type Herbicides 132
I. Introduction 132
II. Natural Plant Growth Regulators 134
III. Synthetic Growth Regulators Related to Indole-3-acetic Acid 144
IV. Other Synthetic Auxins 148
References 168
Chapter 4. Development and Application of New Steric Substituent Parameters in Drug Design 182
I. Introduction 182
II. Development of the New Steric Parameters 187
III. Use of the New Steric Parameters 203
IV. Scope and Limitations 217
References 223
Chapter 5. Computer Technology in Drug Design 226
I. Introduction 226
II. Computer Intelligence Applied to Drug Design 240
III. Conclusion 286
Appendix 290
ACKNOWLEDGMENT 292
References 292
Index 296