Risk Factors for Cerebrovascular Disease and Stroke

Sudha Seshadri, MD Department of Neurology Boston University School of Medicine Investigator, The Framingham Heart Study Boston, MA Stéphanie Debette, MD, PhD Department of Neurology and Epidemiology Paris Diderot University Paris, France

I. Introduction ; 1. Epidemiology of stroke: incidence and prevalence, description of types and subtypes and their relative frequency, definition of risk factors ; II. Genetic risk factors ; 2. Introduction to Genetic risk factors for cerebrovascular disease ; 3. Monogenic forms of stroke and cerebrovascular disease ; 4. Heritability of stroke ; 5. Genetic determinants of ischemic stroke discovered through GWAS ; 6. Genetic risk factors of intracerebral haemorrhage ; 7. Relevance in stroke of genes associated with cardiovascular disease and risk factors/ ; 8. Genetics of Stroke associated with cervical artery dissections ; 9. Genetics of cerebral venous thrombosis ; 10. Genetic risk factors for brain MRI markers of cerebrovascular disease ; III. Environmental risk factors ; 11. Overview of Environmental Risk Factors for Stroke ; 12. Hypertension: the major risk factor for stroke ; 13. Dyslipidemia and Risk of Stroke ; 14. Metabolic risk factors: DM, obesity, metabolic syndrome ; 15. Lifestyle factors and Risk of Stroke: smoking, alcohol, diet, physical activity, sleep ; 16. Risk factors specific to young adults ; 17. Sex-Specific Risk factors for Stroke in Women ; 18. Migraine and Risk of Stroke and Cerebrovascular Disease ; 19. Ethnic, Racial and Geographic Variations in Stroke Risk and Risk Factors ; IV. Integrative approach ; 20. Intermediate markers: Carotid Atherosclerosis ; 21. MRI-based Markers of Cerebrovascular Disease and the Risk of Stroke ; 22. Circulating Biomarkers for Stroke ; 23. Secular trends in Stroke Risk and Risk factors for Stroke