Radiation Protection and Recovery (eBook)

Front Cover 1
Radiation Protection and Recovery 4
Copyright Page 5
Table of Contents 6
Chapter 1. Introduction 8
Chapter 2. Protection of macromolecules in vitroagainst damage by ionizing radiations 10
I. INTRODUCTION 10
II. POSSIBLE MECHANISMS BY WHICH PROTECTIONCAN BE BROUGHT ABOUT 16
III. EXAMPLES OF PROTECTION AGAINST INDIRECT ACTION 24
IV. PROTECTION AGAINST DIRECT ACTION 39
V. RELATION OF PROTECTION AT THE MOLECULAR LEVELTO PROTECTION IN VIVO 46
LITERATURE CITED 48
Chapter 3. Chemical protection to mammalsagainst ionizing radiation 52
I. INTRODUCTIO 52
II. DESIGN OF EXPERIMENTS 54
III. CHEMICAL PROTECTIVE AGENTS 57
IV. MECHANISMS OF PROTECTION 78
LITERATURE CITED 82
Chapter 4. Protection and recovery in bacteriaand fungi 96
I. EFFECT OF CULTURAL CONDITIONS AND PHYSIOLOGICALSTATE ON RADIOSENSITIVITY 97
II. EXPERIMENTAL MODIFICATION OF RADIOSENSITIVITY 101
III. PROTECTION AGAINST MUTATIONS 112
IV. RECOVERY FROM RADIATION DAMAGE 114
V. RECOVERY FROM GENETIC DAMAGE 117
VI. GENERAL DISCUSSION OF PROTECTION AND RECOVERYIN BACTERIA AND FUNGI 119
LITERATURE CITED 121
Chapter 5. Protection and recovery of the cellfrom radiation damage 126
I. INTRODUCTION 126
II. MATERIALS AND TECHNIQUES 128
III. BIOLOGICAL FACTORS IN RADIORESPONSE 130
IV. ENVIRONMENTAL FACTORS IN RADIORESISTANCE 138
V. CONCLUSION 157
LITERATURE CITED 158
Chapter 6. Chromosome aberrations 166
I. INTENSITY AND FRACTIONATION 169
II. CENTPIFUGATION 170
III. STAGE SENSITIVITY 170
IV. EFFECT OF SPINDLE POISONS 170
V. ULTRAVIOLET RADIATION 171
VI. WATER CONTENT 171
VII. TEMPERATURE 172
VIII. CHEMICAL PROTECTION 172
IX. OXYGEN 173
X. CONCLUSION 181
LITERATURE CITED 182
Chapter 7. Protection and recovery fromionizing radiation: Mechanisms inseeds and roots 186
I. INTRODUCTION 186
II. EFFECTS OF IONIZING RADIATIONS ON ROOTS 187
III. EFFECTS OF IONIZING RADIATION ON SEEDS 202
LITERATURE CITED 214
Chapter 8. Genetical protection 223
I. INTRODUCTION 223
II. SPONTANEOUS MUTATIONS 224
III. INDUCED MUTATIONS 225
IV. CONCLUDING REMARKS 245
LITERATURE CITED 247
Chapter 9. Experimental treatment of acutewhole-body radiation injuryin mammals 253
I. INTRODUCTION 253
II. BASIC MECHANISMS IN ACUTE RADIATION DEATH 254
III. HISTORICAL RESUME 255
IV. ISOLOGOUS BONE MARROW 257
V. HOMOLOGOUS BONE MARROW 259
VI. HETEROLOGOUS BONE MARROW 261
VII. SHIELDING PROCEDURES 261
VII. SHIELDING PROCEDURES 261
VIII. RADIATION EFFECTS NOT INFLUENCED BYBONE MARROW THERAPY 262
IX. ACTION OF BONE MARROW 263
X. CELL TYPES RESPONSIBLE FOR REPOPULATION 269
XI. BONE MARROW CELL DOSE 270
XII. ROUTE OF INJECTION 272
XIII. TIME OF INJECTION 272
XIV. LOCALIZATION OF INJECTED CELLS 273
XV. AGE OF RECIPIENT 273
XVI. PRESERVATION AND TISSUE CULTURE OFBONE MARROW 274
XVII. AMOUNT AND TYPE OF IRRADIATION 275
XVIII. USE OF NONLIVING MATERIAL 277
XIX. FOREIGN BONE MARROW REACTION 280
XX. EXPERIMENTAL APPLICATIONS 289
XXI. CLINICAL APPLICATIONS 291
LITERATURE CITED 295
Chapter 10. Modification of delayed somaticeffects of ionizing radiation 316
I. INTRODUCTION 316
II. RADIOLOGICAL FACTORS 316
III. PHYSIOLOGICAL FACTORS 318
IV. HYPOXIA 319
V. SULFHYDRYL-CONTAINING COMPOUNDS 320
VI. POLYPHENOL DERIVATIVES 321
VII. PARTIAL-BODY SHIELDING 322
VIII. TRANSPLANTATION OF HEMOPOIETIC CELLS 323
CONCLUSION 325
CONCLUSION 325
LITERATURE CITED 325
Chapter 11. Effect of radiation onantibody formation 329
I. INTRODUCTION 329
II. SITE OF ANTIBODY FORMATION 330
III. THEORIES OF ANTIBODY FORMATION 332
IV. TEMPORAL RELATION BETWEEN ANTIGEN INJECTIONAND IRRADIATION 334
V. ANTIBODY RESPONSE DURING MAXIMUM DEPRESSIONPERIOD AFTER VARYING X-RAY DOSES 340
VI. EFFECT OF RADIATION ON THE RECOGNITION FACTOROF ANTIBODY-FORMING CELLS 344
VII· MODIFICATION OF THE IMMUNE MECHANISM OF ANIRRADIATED ANIMAL 347
VIII. LETHALLY X-RAYED ISOLOGOUS MICE AS IN VIVO TISSUECULTURES OF ANTIBODY-FORMING CELLS 355
IX. SUMMARY 358
LITERATURE CITED 359
Chapter 12. Photoreactivation 367
I. INTRODUCTION 367
II. GENERAL FEATURES 367
III. THE MECHANISM 378
IV. GENERAL REMARKS 387
LITERATURE CITED 388
INDEX 396