Endocrine Aspects of Disease Processes (eBook)

Front Cover 1
Endocrine Aspects of Disease Processes 4
Copyright Page 5
Table of Contents 10
Participants 6
Preface 8
Endocrine Aspects of disease Processes 14
Chapter 1. Hypothalamic Hormones Regulating the Secretions of the Anterior Pituitary 16
Abstract 24
Acknowledgements 25
References 25
Discussion 28
Chapter 2. Corticosterone-binding by Transcortin and Pituitary-Thyroid-adrenocortical Interactions in the Rat 33
Abstract 35
Acknowledgements 35
References 36
Discussion 38
Chapter 3. Calcitonin—Hormone of the Ultimobranchials 40
Introduction 40
Chemistry and Assay 43
Ultimobranchial Origin of Calcitonin 45
Action of Calcitonin 49
Calcitonin in Man 50
Homeostatic Role of Calcitonin 51
Abstract 52
Acknowledgements 53
References 53
Discussion 56
Chapter 4. Brain Monoamines and Thyroid Hormones on theEmotional Stress Induced by Sympathomimetic Agents in Aggregated Animals 60
Materials and Methods 61
Results 62
Discussion 79
Abstract 82
Acknowledgements 84
References 84
Discussion 86
Chapter 5. On the Participation of Polypeptides and Biogenic Amines in the Acute Inflammatory Reactions 87
Histamine and Inflammatory Reactions 88
Intrinsic Histamine 89
Insufficiency of the Histamine Mediation 89
Participation of 5-Hydroxytryptamine (Serotonin) 91
The Kinin System 91
The Probable Mediators of the Acute Inflammatory Reactions 93
Experimental Proof of the Participation of Kininsin the Inflammatory Reaction 94
Release of Bradykinin in the Interstitial Spaces 95
Indirect Methods 96
Research on Anti-bradykinin Agents 99
Abstract 101
References 101
Discussion 106
Chapter 6. Pharmacology of Aggression 109
I. Reaction Phenomena 110
II. Lesion Phenomena 130
III. Pharmacology of Aggression 133
Conclusion 140
Abstract 141
References 143
Discussion 150
Chapter 7. Serum Aminopexy 151
Introduction 151
Techniques for the Evaluation of Aminopexy 152
Serum Histaminopexy Studies in Man 155
Discussion 156
Abstract 158
References 159
Discussion 160
Chapter 8. Brain Plasticity: Hormones and Stress 164
Introduction 164
Hormones 164
Stress: Environmental Changes 167
Abstract 171
References 171
Chapter 9. Sleep-wakefulness Patterns and Hormones 173
Abstract 184
Acknowledgements 185
References 185
Chapter 10. Endocrine Factors in the Etiology of Peptic Ulcer 188
A. Adrenal Hormones 189
B. Pituitary Hormones 191
C. Sex Hormones 199
D. Syndrome of Polyendocrine Tumors 203
General Conclusion 203
Abstract 203
References 205
Discussion 208
Chapter 11. Blood Sugar Levels and Allergies 214
Glycemia and the Dextran Anaphylactoïd Reaction in Rats 214
TARIF, The Transferable Anaphylactoïd Reaction Inducing Factor 220
Anaphylaxis and Immune Hemolytic Anemia 224
Histamine and Compound 48-80 232
The Oscillations of Blood Sugars and Susceptibility to Allergy 238
Conclusions 240
Abstract 241
Acknowledgements 242
Addendum 242
References 242
Discussion 244
Chapter 12. Antineoplastic Effects of BCG and Other Agents 247
Materials and Methods 247
Experiments and Results 248
Discussion 253
Abstract 256
Acknowledgements 256
References 257
Discussion 258
Chapter 13. Thymus and Inflammation 262
Materials and Methods 262
Results 262
Abstract 264
Acknowledgements 264
References 265
Discussion 266
Chapter 14. The Renin-angiotensin-aldosterone System in Renal Hypertension 271
1) Renin Content of Kidneys in Renal Hypertension 271
2) Plasma Renin and Angiotensin in Renal Hypertension 272
3) Effects of Antirenin on Hypertension 273
4) Production of Hypertension with Angiotensin and Renin 273
5) Determinations of Aldosterone 274
Discussion 275
Abstract 277
Acknowledgements 278
References 278
Discussion 282
Chapter 15. Studies on the Pathogenesis of Adrenal-regeneration and Methylandrostenediol Hypertension 284
Materials and Methods 285
Results 287
Discussion 302
Abstract 307
Acknowledgements 308
References 309
Discussion 312
Chapter 16. High Blood Pressure in Rats Protected Against Acute Post-enucleation Adrenal Insufficiency and Its Bearing on the Etiology of Adrenal-regeneration Hypertension 315
Experiment 1 316
Experiment 2 320
Materials and Methods 321
Results 322
Discussion 327
Abstract 330
Acknowledgements 331
References 331
Discussion 332
Chapter 17. A Radioautographic Survey of the Formation and Fate of Connective Tissue Giant Cells in Selye's Granuloma Pouch 338
Introduction 338
Materials and Methods 338
Observations 339
Discussion and Conclusions 342
Abstract 345
Acknowledgements 346
References 346
Discussion 348
Chapter 18. Peripheral Vasodilatation and Thymic Tumors in Magnesium-Deficient Rats 350
Materials and Methods 353
Results 354
Discussion 358
Abstract 360
Acknowledgements 361
References 361
Discussion 364
Chapter 19. Action of Hormones on the Progression of Magnesium Deficiency Syndrome in Rats 369
Materials and Methods 370
Results 371
Discussion 388
Abstract 390
Acknowledgements 391
References 392
Discussion 394
Chapter 20. The Role of the Adrenal Cortex in the Pathogenesis of a Spontaneous, Hereditary Congestive Heart Failure 401
Materials and Methods 402
Results 404
Discussion 409
Abstract 413
Acknowledgements 415
References 415
Discussion 418
Chapter 21. The Cause of Coronary and Cerebral Artery Thrombosis in Man 420
Abstract 423
References 423
Discussion 424
Chapter 22. Sensitization by Renal Hypertension for the Production of Thrombohemorrhagic Lesions with Endotoxin 427
Materials and Methods 427
Results 428
Discussion 437
Abstract 438
Acknowledgements 439
References 439
Discussion 440
Chapter 23. Influence of Corticoids on Coagulation and Thrombosis in Rat: Possibility of a Serum-protein Related Effect 442
Materials and Methods 443
Results and Discussion 444
Abstract 449
Acknowledgements 450
References 451
Discussion 452
Index 460