Coronary Vasodilators (eBook)
220 Seiten
Elsevier Science (Verlag)
978-1-4831-5274-5 (ISBN)
The book is organized into four chapters. Chapter I is devoted to the influences controlling coronary blood flow. Chapter II reviews the experimental methods commonly used in pharmacological research with a critical assessment of their possibilities and limitations. Chapter III discusses methods recommended by clinical research workers for evaluating the effectiveness of anti-anginal medications in the patient. Chapter IV describes pharmacology and clinical features of coronary vasodilators. The substances considered are group into four sections. The first contains the coronary vasodilator drugs actually used in cardiovascular therapeutics. The second consists of sympathicomimetic substances which modify general and local hemodynamic conditions profoundly and thus produce increased coronary flow. In the third section are brought together drugs used on man for particular therapeutic properties which have coronary vasodilator action, uncertain in the case of some, and which, for various reasons, cannot be used in the treatment of angina. The fourth section collects together a variety of substances, most of which are not drugs, reported in the literature as having vasodilator activity at coronary circulation level.
Coronary Vasodilators assesses the state of knowledge of the pharmacological effects, the mechanisms responsible for these effects, and the therapeutic importance of classical drugs as well as recent medications on which experimental and clinical investigations are still too few to allow of definite judgment. The book is organized into four chapters. Chapter I is devoted to the influences controlling coronary blood flow. Chapter II reviews the experimental methods commonly used in pharmacological research with a critical assessment of their possibilities and limitations. Chapter III discusses methods recommended by clinical research workers for evaluating the effectiveness of anti-anginal medications in the patient. Chapter IV describes pharmacology and clinical features of coronary vasodilators. The substances considered are group into four sections. The first contains the coronary vasodilator drugs actually used in cardiovascular therapeutics. The second consists of sympathicomimetic substances which modify general and local hemodynamic conditions profoundly and thus produce increased coronary flow. In the third section are brought together drugs used on man for particular therapeutic properties which have coronary vasodilator action, uncertain in the case of some, and which, for various reasons, cannot be used in the treatment of angina. The fourth section collects together a variety of substances, most of which are not drugs, reported in the literature as having vasodilator activity at coronary circulation level.
Front Cover 1
Coronary Vasodilators 5
Copyright Page 6
Table of Contents 7
Preface 11
Introduction 15
CHAPTER I. Physiological Factors Determining the Coronary Blood Flow
19
CHAPTER II. Critical Analysis of Methods for Measurement of Changes in the Lumen of the Coronary Vessels
27
1. METHODS ON THE ISOLATED HEART BASED ON THE LANGENDORFF TECHNIQUE
27
2. METHODS ON THE ANESTHETIZED ENTIRE ANIMAL, WITH THE HEART IN SITU, INVOLVING CANNULIZATION OF THE CORONARY VESSELS
42
3. METHODS ON THE UNANÆSTHETIZED, ENTIRE ANIMAL
53
4. THE CALORIMETRIC METHOD 58
5. METHODS BASED ON THE EMPLOYMENT OF RADIOACTIVE SUBSTANCES
58
6. VARIOUS NON-QUANTITATIVE METHODS 60
CHAPTER III. Clinical Methods for Assessment of the Therapeutic Value of Anti-anginal Medications
63
1. OBJECTIVE METHODS 66
2. SUBJECTIVE METHODS 74
3. CONCLUSIONS ON METHODS OF CLINICAL ASSESSMENT
79
CHAPTER IV. Coronary Vasodilators : Pharmacology and Clinical Features
81
SECTION 1 CORONARY VASODILATOR SUSED IN CARDIOVASCULAR THERAPY
82
SECTION 2 SYMPATHICOMIMETIC AMINES
170
SECTION 3 SUBSTANCES HAVING CORONARY VASODILATOR EFFECTS, CERTAIN OR UNCERTAIN, BUT NOT USED AS SUCH
177
SECTION 4 MISCELLANEOUS SUBSTANCES 190
General Considerations 197
Bibliography 199
Index 251
Erscheint lt. Verlag | 22.10.2013 |
---|---|
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
ISBN-10 | 1-4831-5274-X / 148315274X |
ISBN-13 | 978-1-4831-5274-5 / 9781483152745 |
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