Bone Cancer -

Bone Cancer (eBook)

Primary Bone Cancers and Bone Metastases

Dominique Heymann (Herausgeber)

eBook Download: PDF | EPUB
2014 | 2. Auflage
736 Seiten
Elsevier Science (Verlag)
978-0-12-416728-5 (ISBN)
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Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.


  • Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work
  • Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system
  • Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases
  • Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

List of Contributors


Catherine Alix-Panabieres, MD, PhD,     University Institute of Clinical Research UM1 - EA2415 - Epidemiology, Biostatistics & Public Health, Montpellier, France

Matthias J.E. Arlt, Phd,     Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, Zürich, Switzerland

Regis Bataille, MD, PhD,     Institut de Cancérologie de l’Ouest, Angers, France

Gillian Bedard, BSc(C),     Department of Radiation Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Dominik R. Berthold, MD,     Department of Medical Oncology, University Hospital Canton Vaud, Switzerland

Paolo Bianco, MD,     Stem Cell Lab, Anatomic Pathology, Sapienza University of Rome, Rome, Italy

Frédéric Blanchard, PhD,     INSERM UMR 957, Faculté de Médecine, F-44035 Nantes; Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France

Jean-Yves Blay, MD, PhD,     Medicine Department, Centre Léon Bérard; University Claude Bernard Lyon I; CRCL UMR5286/INSERM 1052, LYRIC (INCA-4664) Lyon, France

Damien Bolton, MD,     Department of Urology, Austin Hospital, University of Melbourne; Department of Surgery, Heidelberg, Melbourne, Australia

Marina Bolzoni, MS,     Hematology, University of Parma, Parma, Italy

Walter Born, PhD,     Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, Zürich, Switzerland

Sander M. Botter, PhD,     Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, Zürich, Switzerland

Corinne Bouvier, MD, PhD,     Service d’Anatomie pathologique et de Neuropathologie, Hôpital La Timone, CHU de Marseille, UMR 911, Faculté de Médecine de Timone, Marseille, France

Bénédicte Brounais-Le Royer, PhD,     INSERM UMR 957, Faculté de Médecine, F-44035 Nantes; Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France

Nicola J. Brown, PhD,     Microcirculation Research Group, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

Jeroen T. Buijs, PhD,     Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands

Daniel F. Camacho, BS,     Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA

Preston Campbell, PhD,     Department of Medicine, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN, USA

Daniel Chappard, MD, PhD,     GEROM Groupe Etudes Remodelage Osseux et bioMatériaux – LHEA, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, LUNAM Université, 49933 Angers Cedex, France

Stephane Chartier, BS,     Department of Pharmacology, University of Arizona, Tucson, AZ, USA

Hong Chou, MBBS, MMED,     Vancouver General Hospital, Vancouver, BC, Canada

Edward Chow, MBBS, MSc, PhD, FRCPC,     Department of Radiation Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Ronald Chow, BSc,     Department of Radiation Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Dimitrios Christoulas, MD, PhD,     Department of Hematology, 251 General Air Force Hospital, Athens, Greece

Anne-Marie Cleton-Jansen, PhD,     Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Philippe Clézardin, PhD,     INSERM, UMR 1033, Lyon; University of Lyon, Villeurbanne, France

Denis R. Clohisy, MD,     Department of Orthopaedic Surgery and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

Robert Coleman, MD,     Yorkshire Cancer Research Professor of Medical Oncology, Sheffield Cancer Research Centre, Weston Park Hospital, Sheffield, UK

Nadège Corradini, MD,     INSERM, Equipe labellisée LIGUE 2012, UMR957; Université de Nantes, Nantes Atlantique Universités, laboratoire de Physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitives, Faculté de Médecine; University Hospital, Hôtel Dieu, CHU de Nantes; Service d’oncologie pédiatrique, Hôpital Mère-Enfant, Nantes, France

Martine Croset, PhD,     INSERM, UMR 1033, Lyon; University of Lyon, Villeurbanne, France

Gonzague de Pinieux, MD, PhD,     Service d’Anatomie et Cytologie Pathologiques, Hôpital Trousseau, CHRU de Tours, Faculté de Médecine, Université François Rabelais, Tours; INSERM, UMR957, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Equipe Labellisée Ligue Contre le Cancer 2012, Nantes, France

Olfa Derbel, MDF,     Medicine Department, Centre Léon Bérard, Lyon, France

Vincenzo Desiderio, PhD,     Department of Experimental Medicine, Section of Embryology and Histology, Second University of Naples, Naples, Italy

James R. Edwards, DPhil,     Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Headington, Oxford, UK

Florent Elefteriou, PhD,     Departments of Medicine, Pharmacology, and Cancer Biology, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN, USA

Michelle Fealk, BA,     Department of Pharmacology, University of Arizona, Tucson, AZ, USA

Adrienne M. Flanagan, MD, PhD,     UCL Cancer Institute, London; Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK

Pierrick G.J. Fournier, PhD,     Division of Endocrinology, Indiana University School of Medicine, Indianapolis, IN, USA

Olivia Fromigué, PhD,     INSERM UMR-1132, and Université Paris Diderot, Sorbonne Paris Cité, Paris, France

Bruno Fuchs, MD, PhD,     Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, 8008 Zürich, Switzerland

Dingcheng Gao, PhD,     Department of Cardiothoracic Surgery; Neuberger Berman Lung Cancer Research Center; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY, USA

Panagiotis D. Gikas, MD,     Sarcoma Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK; Institute of Orthopaedics and Musculoskeletal Science, UCL, London, UK

Nicola Giuliani, MD, PhD,     Hematology, University of Parma, Parma, Italy

Michael Gnant, MD,     Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Austria

Anne Gomez-Brouchet, MD, PhD,     Service d’Anatomie et Cytologie Pathologiques, CHU Rangueil, Toulouse; Faculté de Médecine Toulouse-Rangueil, France

Georg Gosheger, MD,     Department of Orthopaedics, University Hospital of...

Erscheint lt. Verlag 13.10.2014
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Orthopädie
ISBN-10 0-12-416728-4 / 0124167284
ISBN-13 978-0-12-416728-5 / 9780124167285
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