Manual of Ovulation Induction & Ovarian Stimulation Protocols

Gautam Allahbadia MD DNB FNAMS Consultant Fertility Physician, Dr LH Hiranandani Center for Human Reproduction, Dr LH Hiranandani Hospital, Powai, Mumbai, India Rubina Merchant Deccan Fertility Clinic, Rotunda – Center for Human Reproduction, Mumbai, India

Fundamentals of Stimulation





Regulation of the menstrual cycle and the effect of controlled ovarian hyperstimulation on cycle characteristics
Regulation of Gonadotropin Secretion
The role of gonadotropins in follicular development and their use in ovulation induction protocols for assisted reproduction
Predictors of ovarian response to controlled ovarian stimulation: are they useful?
Clinical significance of antral follicle count and anti-Müllerian hormone in predicting the stimulation outcome
Human Ovulation and Transvaginal Sonography
The significance of monitoring folliculogenesis
Identification of patients at high risk for excessive response to ovarian stimulation
The impact of repeated ovulation stimulations on the ovarian reserve
Luteinizing hormone activity in ovarian stimulation for IVF: is it Ovulation Induction and Ovulation indispensible?
Luteal phase support in controlled ovarian hyperstimulation protocols: why and how?


Ovarian Stimulation Regimens





Ovarian Stimulation Protocols
Clomiphene Citrate for Ovarian Stimulation
Combination Protocols Using Clomiphene Plus Gonadotropins
Route of Administration of Gonadotropins and Ovarian Response
Clinical Application of Recombinant Follicle Stimulating hormone
Induction Protocols of the 2000’s Using r-hLH and r-Hcg
Step-up Protocols
Step-down protocols for ovulation induction
The Role of Gonadotropin-Releasing Hormone Agonists in Ovulation Induction
Gonadotropin-releasing hormone antagonist protocols: fixed versus flexible
GnRH agonists vs. GnRH antagonists for ovarian stimulation: pros and cons
Fine-tuning the Role of GnRH Antagonists in ART Programs
Evaluation of luteal phase in GnRH agonist/antagonist IVF protocols
Recombinant human follicle-stimulating hormone vs. highly purified human menopausal gonadotrophin for controlled ovarian stimulation in GnRH agonist down-regulated cycles
Can endogenous LH support treatment with rFSH only in a GnRH antagonist protocol in normogonadotropic patients?
The efficacy of recombinant LH supplementation for controlled ovarian stimulation in r-FSH and GnRH-agonist protocols
Substitution of recombinant FSH (rFSH) by low-dose hCG in the late follicular phase in a GnRH antagonist protocol: Is it clinically effective?
The benefit of luteal estradiol pre-treatment in GnRH antagonist protocols vs. long GnRH agonist protocols
Impact of long GnRH agonist and GnRH antagonist stimulation protocols on endometrial receptivity
The efficacy of clomiphene citrate in preventing a premature LH surge during controlled ovarian stimulation with human menopausal gonadotrophins (hMG)
Pretreatment with combined oral contraceptives prior to stimulation: does it help?


Aromatase inhibitors for Ovarian Stimulation





Aromatase inhibitors for ovulation induction: indications and clinical outcomes
Clomiphene citrate vs. aromatase inhibitors: mechanism of action
Clinical efficacy and safety of letrozole vs. clomiphene citrate for ovulation induction in women with polycystic ovary syndrome
Ovulation Induction in PCOS
Management strategies for ovulation induction CC-resistant PCOS women
Induction of Monofolliculogenesis in Patients with Polycystic Ovary Syndrome
Low-dose step-down regimen for ovulation induction in PCOS
Chronic ultra-low-dose step-up protocol for patients with polycystic ovary syndrome
GnRH agonist vs. antagonist protocols for controlled ovarian stimulation in women with PCOS
Influence of BMI on the IVF outcome in PCOS patients undergoing stimulation with GnRH agonists or antagonists
Adjunctive Glucocorticoids in Ovulation Induction for Polycystic Ovarian Syndrome
Metformin Treatment of Clomiphene-Resistant Polycystic Ovary Syndrome
Mechanism of action of metformin for ovulation induction in PCOS patients
Clomiphene citrate, Metformin, or both for the treatment of anovulatory women with polycystic ovary syndrome: evidence-based recommendations
Metformin and clomiphene citrate (CC) vs. highly purified FSH for ovulation induction in CC-resistant women with PCOS
The current place of Metformin in infertile patients with PCOS: an evidence-based approach
Laparoscopic ovarian drilling for surgical induction of ovulation in polycystic ovary syndrome


Ovulation triggering





Role of GnRH Agonists as an Ovulation Trigger
Recombinant LH, recombinant hCG and GnRH agonist to trigger ovulation: a critical evaluation
LH and FSH surges for final oocyte maturation: Is a dual surge beneficial?


Complications of COH





Complications of ovulation induction
Ovarian hyperstimulation syndrome: prevention strategies
The role of in vitro maturation in high responders and patients at risk of OHSS undergoing assisted reproductive technology


Poor Responders





Cancelled Cycles in Poor Response—What Next? Ovulation Induction and Ovulation
Management options for poor responders to controlled ovarian stimulation
The efficacy of microdose GnRH agonist flare (MF) vs. GnRH antagonist/Letrozole protocols in poor responders undergoing in vitro fertilization
Optimum maximal gonadotropin dosage used in microdose flare-up cycles
Role of androgens in the treatment of patients with low ovarian response
Addition of growth hormone to stimulation protocols for poor responders: is it beneficial?
Criteria for cycle cancellation in poor responders to ovarian stimulation
Contribution of in vitro maturation to ovarian stimulation cycles in poor responder patients


Mild Stimulation Protocols and Natural Cycle IVF





Embarking on natural cycle IVF: When and how?
The value of modified natural cycle IVF in normal ovarian responders
Advances in Stimulation Science
Long-acting Recombinant FSH (FSH-CTP, Corifollitropin Alfa)
Can corifollitropin alfa replace recombinant FSH (rFSH) for ovarian stimulation using a gonadotrophin-releasing hormone antagonist protocol prior to IVF/ICSI?
Applicability and reproducibility of Sonography-based Automated Volume Count (SonoAVC) for monitoring folliculogenesis
The ideal stimulation protocol: Is there one?