Theranostics, Gallium-68, and Other Radionuclides

A Pathway to Personalized Diagnosis and Treatment

Richard P. Baum, Frank Rösch (Herausgeber)

Buch | Softcover

XVIII, 578 Seiten

2014 | 2013
Springer Berlin (Verlag)
978-3-642-44160-8 (ISBN)

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This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

From the contents: Ge-68/Ga-68 generators.- Automation strategies in Ga-68 radiopharmaceutical preparations.- Post-processing via cation exchange cartridges.- Gallium-68 generator integrated system: elution - purification - concentration integration.- Purification and labelling strategies for 68 Ga from 68 Ge/ 68 Ga generator eluate.- 67 Ga and 68 Ga purification studies.- The diversity of [ 68 Ga]Ga-based imaging agents.- Nanoparticles and phage display selected peptides for imaging and therapy of cancer.- "Click" cyclized gallium-68 labeled peptides for molecular imaging and therapy: Synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system.- Early experience with 68 Ga-DOTATATE preparation .- 68 Ga-radiopharmaceuticals for PET imaging of infection and inflammation.- 68 Ga-labeled bombesin analogs for receptor mediated imaging.- A novel 68 Ga-labelled pteroic acid-based PET tracer for tumour imaging via the folate receptor.- Measurement of protein synthesis: In vitro comparison of 68 Ga-DOTA-puromycin, [ 3 H]tyrosine and 2-fluoro-[ 3 H]tyrosine.- Hypoxia imaging agents labeled with positron emitters.- Lu-177/Y-90 intermediate affinity monoclonal antibodies targeting EGFR and HER2/c-neu: preparation and preclinical evaluation.- Divergent role of 68 Ga labeled somatostatin analogs in the work-up of patients with NETs.- Differential uptake of 68 Ga-DOTATOC and 68 Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumours.

From the reviews:

"The general themes of this book (theranostics and peptide receptor-targeted radiotherapy) derive from evolving successes in the use of generator-produced ⁶⁸Ga for molecular imaging of disease. ... This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in ⁶⁸Ga and peptide receptor radionuclide therapy-based theranostics for preclinical and emerging clinical applications." (Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013)

Erscheint lt. Verlag	20.9.2014
Reihe/Serie	Recent Results in Cancer Research
Zusatzinfo	XVIII, 578 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	902 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Nuklearmedizin
	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
Schlagworte	Gallium-68 • Neuroendocrine tumors • PET radiopharmaceuticals • Radiaton Oncology • Radionuclides • Theranostics
ISBN-10	3-642-44160-2 / 3642441602
ISBN-13	978-3-642-44160-8 / 9783642441608
Zustand	Neuware