Cognitive Impairment and Dementia in Parkinson's Disease

Professor Murat Emre was born in 1956 in Eregli, Turkey. After studying medicine at the Istanbul Faculty of Medicine he trained in Neuroscience and Clinical Neurology at the University of Zurich. He then worked in the fields of neurorehabilitation and clinical research in Switzerland for several years. He trained in movement disorders with Prof. David Marsden at the Queen Square National Hospital for Nervous Diseases, London and in behavioral neurology with Prof. Marsel Mesulam at the Beth Israel Hospital and Harvard Medical School. In 1996 he was appointed as Professor of Neurology at the Istanbul Faculty of Medicine where he started the Behavioral Neurology and Movement Disorders Unit, which he has chaired for many years. His research interests are in Parkinson's disease and related disorders, in particular cognitive aspects of the disease, Alzheimer's disease and related dementias.

1. Introduction ; 2. Epidemiology of dementia associated with Parkinson's disease ; 3. General features, mode of onset and course of dementia in Parkinson's disease ; 4. Cognitive profile in Parkinson's disease dementia ; 5. Neuropsychiatric symptoms in Parkinson's disease dementia ; 6. Interaction between affect and executive functions in Parkinson's disease ; 7. Motor symptoms and phenotype in patients with Parkinson's disease dementia ; 8. Interaction between cognition and gait in patients with Parkinson's disease ; 9. Disorders of sleep and autonomic function in Parkinson's disease dementia ; 10. Structural and functional neuroimaging in patients with Parkinson's disease dementia ; 11. Biomarkers for cognitive impairment and dementia in Parkinson's disease ; 12. Electrophysiological and other auxiliary investigations in patients with Parkinson's disease dementia ; 13. Genetic basis of dementia in Parkinson's disease ; 14. Neurochemical pathology of Parkinson's disease dementia and dementia with Lewy bodies ; 15. Pathological correlates of dementia in Parkinson's disease ; 16. Epidemiology, diagnosis and correlates of Mild Cognitive Impairment in Parkinson's disease ; 17. The pathophysiological and prognostic heterogeneity of Mild Cognitive Impairment in Parkinson's disease ; 18. Spectrum of Lewy body dementias: relationship of Parkinson's disease dementia to dementia with Lewy bodies ; 19. Spectrum of disorders with dementia and Parkinsonism ; 20. Diagnosis of dementia in Parkinson's disease ; 21. Management of Parkinson's disease, dementia and dementia with Lewy bodies ; 22. Parkinson's disease: what will the future bring?