Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome

Dr. Kazunari Kaneko obtained PhD in division of Medicine, Jyuntendo University, Japan in 1989. He started his career as bucho at the Ishioka Ishikai clinic in the same year. He went back to Jyuntendo University to be assistant professor in 1992. There He promoted to lecturer, and then associate professor. He moved to Kansai Medical University as full Professor in 2005. He is the top researcher in the field of Pediatric and Nephrology. He is the bourd member of the Japanese Society for Pediatric Nephrology, Japanese society of Pediatric Radiology, Japanese society of Pediatric Urology, and Japanese society of Pediatric Psychiatry and Nephrology.

Part 1. Introduction.- 1. History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome.- Part 2. Minimal-change nephrotic syndrome (MCNS).- 2. Hemopexin in Minimal Change Nephrotic Syndrome.- 3. Angiopoietin-like-4 (Angptl4) in MCNS.- 4. Co-stimulatory molecule CD80 (B7.1) in MCNS.- 5. Energy and Mammalian target of rapamycin complex 1 (mTORC1) in minimal change nephrotic syndrome.- 6. The role of c-mip in the pathogenesis of Minimal Change Nephrotic Syndrome.- 7. REGULATORY T-CELLS AND OXIDATIVE STRESS IN MINIMAL CHANGE NEPHROPATHY.- 8. CYTOKINES AS ACTIVE FACTORS IN MINIMAL CHANGE NEPHROTIC SYNDROME.- Part 3. Focal segmental glomerulosclerosis (FSGS).- 9. Soluble urokinase-type plasminogen activator receptor (suPAR) in Focal Segmental Glomerulosclerosis.- 10. CYTOKINES AS ACTIVE FACTORS IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS.- Part 4. Idiopathic Membranous Nephropathy (IMN).- 11. M-Type Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) in Membranous Nephropathy.- 12. Cationic Bovine Serum Albumin as Cause of Membranous Nephropathy: From Mice to Men.- Part 5. Treatment in Idiopathic Nephrotic Syndrome.- 13. Podocytes as a direct target of drugs used in Idiopathic Nephrotic Syndrome.