Biomedical Optical Instrumentation and Laser-Assisted Biotechnology

I. Basic Physics of Light-Biomatter Interactions and Tissue-Optics.- Some Future Trends of Laser Biomedicine.- Modelling Light Propagation in Tissues.- Dynamics of Optical Properties.- II. Light-Induced Effects in Biological Systems.- Derepression of Genome and Alteration of DNA Template Activity in Nonproliferating Cells by means of UV and Visible Laser Radiation.- Photosensitized Processes in vivo: Photodiagnostic and Phototherapeutic Applications.- Laser Induced Stimulation of Blood Platelet Aggregation.- Investigation of Skin Sensitivity Due to Visible and Near-Infrared Laser Radiation.- III. Optical Diagnostic Techniques and Instrumentation.- Reflectance Spectroscopy with Optical Fiber Devices and Transcutaneous Bilirubinometers.- Time-Resolved Reflectance for the Assessment of the Optical Properties of Tissues.- Recent Development in Laser Doppler Perfusion Imaging for Two-Dimensional Tissue Blood Flow Mapping.- Frequency-Domain Optical Spectroscopy and Imaging of Tissues.- Fluorescence Lifetime-Resolved Imaging Microscopy (FLIM).- Automation of Diagnostic and Therapeutic Systems for Medical Applications of Lasers.- Therapeutic Lasers Effectiveness and Dosimetry.- Tunable Diode Laser Detection of Small Traces of Gases for Medical Diagnostics.- Combined Spectroscopic and Molecular Mechanics Investigation of the Photobleaching and Photoproduct Fromation of Photoporphyrin by ALA Application to in vivo Systems.- IV. Optical Therapeutic Instrumentation and Applications.- Time-Resolved Imaging of Acoustic Effects Induced in Air and in Water by Laser Ablation of Organic Tissue.- 980 nm High Power Diode Laser in Surgical Applications.- Surgical Properties and Applications of Sealed-Off CO2 Lasers.- Development of Pulsed Solid State Lasers for Ophthalmology in Romania.- Electro-Optical Instrumentation for Laser-Based Refractive Eye Microsurgery.- The CO2 Laser in Laryngeal Surgery.- Measurement of Pressure Waves Induced Inside the Eye by Excimer Laser Ablation of the Cornea.- How Far is a Prototype from the Market: The Experience with Bilitec 2000.- V. Optical Tomography: Initial Applications in Bio-Medicine.- Optical Coherence Tomography: Principles, Instrumentation, and Biological Applications.- Early Clinical Results of Time-of-Flight Optical Tomography in a Neonatal Intensive Care Unit.- VI. Optical Sensors and Applications.- Fluorescence-Based Optical Sensors for Biomedical Applications.- Surface Plasmon Resonance for Biosensing.- The use of Fiber Optic Sensors in in vivo Monitoring.- Silylated Optrodes for Biomedical Applications.- VII. Laser-Assisted Biotechnology.- Laser Technology in Molecular Biology.- Biological Applications of Light Forces.- VIII. Index.