The Sepsis Text

Generalities.- Sepsis: The Magnitude of the Problem.- Diagnosis and Source of Sepsis: The Utility of Clinical Findings.- Organ Failure.- Markers of Sepsis.- Genetic Predisposition.- Quantifying Risk in Sepsis: A Review of Illness Severity and Organ Dysfunction Scoring.- Pathophysiology.- The Pathogenesis of Gram-Negative Sepsis.- The Pathophysiology of Gram-Positive Shock.- Immunopathogenesis of Gram-Negative Shock.- Involvement of Pro- and Anti-Inflammatory Cytokines in Sepsis.- Pathophysiology of Immunodepression in ICU Patients.- Pathophysiology of Sepsis: The Role of Nitric Oxide.- Apoptosis and the Resolution of Inflammation in Sepsis.- Microvascular Alterations in Sepsis.- Cytopathic Hypoxia.- Monitoring Systems.- Invasive Hemodynamic Monitoring.- Value of SvO2 in Sepsis.- Blood Lactate Concentrations in Sepsis.- Veno-Arterial PCO2 Gradient.- Gas Tonometry.- General Support.- General Hemodynamic Support.- Fluid Administration.- Blood Transfusion and Sepsis.- Catecholamine Therapy.- Regional Effects of Catecholamines.- Management of Respiratory Dysfunction in Patients with Severe Sepsis.- The Role of Nutritional Support in Sepsis.- Microbial Aspects.- The Sources of Sepsis.- Catheter-Related Sepsis.- Control of the Source of Sepsis.- Empirical Antibiotic Therapy for Patients with Severe Sepsis and Septic Shock.- Candida Infections in the Intensive Care Unit.- Why, When, and How to Isolate ICU Patients.- Complications.- The Lung in Sepsis.- The Heart in Sepsis.- The Brain in Sepsis.- The Gut in Sepsis.- The Kidney in Sepsis.- The Coagulation System in Sepsis.- Anti-sepsis Therapies.- Shoulder Fever be Treated in Sepsis?.- Anti-Cytokine Therapy.- Heat Shock Proteins and Sepsis: A Hot Story.- Immunodepression in the Surgical Patient and Increased Susceptibility to Infection.- The Place of Corticosteroids.- The Place of Immunonutrition.- Interference with the Coagulation System.- Hemofiltration and Plasmapheresis.- Endotoxin Analogs in the Treatment of Septic Shock.- Vaccines Against Bacterial Endotoxins.