Organ-Selective Actions of Steroid Hormones -

Organ-Selective Actions of Steroid Hormones

Buch | Softcover
XIV, 184 Seiten
2014 | 1. Softcover reprint of the original 1st ed. 1995
Springer Berlin (Verlag)
978-3-662-09155-5 (ISBN)
53,49 inkl. MwSt
Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.

1 Development of Tissue-Selective Estrogen Receptor Modulators.- 2 Estrogen-Receptor and Antiestrogen-Receptor Complexes: Cell- and Promoter-Specific Effects and Interactions with Second Messenger Signaling Pathways.- 3 Analysis of Genetically Altered Mice Without Glucocorticoid Receptor.- 4 Organ-Selective Actions of Tamoxifen and Other Partial Antiestrogens.- 5 Progestin Regulation of Cell Proliferation in the Breast and Endometrium.- 6 Central Versus Endometrial Effects of Antiprogestins: Is Endometrial Selectivity Possible?.- 7 Androgen Action on the Bone.- 8 General Principles of Vitamin D Action and Mechanism-Based Search for Analogs with Specific Actions.- 9 Organ-Specific Actions of Vitamin D Analogs: Relevance of Rapid Effects.- Previous Volumes Published in this Series.

Erscheint lt. Verlag 23.8.2014
Reihe/Serie Ernst Schering Foundation Symposium Proceedings
Zusatzinfo XIV, 184 p. 38 illus.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 311 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Studium 2. Studienabschnitt (Klinik) Humangenetik
Schlagworte Gewebe • Gewebe (Physiol.) • hormone replacement therapy • Hormone Therapy • Hormontherapie • Osteoporose • Osteoporosis • Promoter • Steroide • Steroids • Tissue specificity • Vitamin D
ISBN-10 3-662-09155-0 / 3662091550
ISBN-13 978-3-662-09155-5 / 9783662091555
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich
Eine sehr persönliche Geschichte | Der New York Times-Bestseller

von Siddhartha Mukherjee

Buch | Softcover (2023)
Ullstein Taschenbuch Verlag
21,99
Die revolutionäre Medizin von morgen (Lifespan)

von David A. Sinclair; Matthew D. LaPlante

Buch | Softcover (2020)
DuMont Buchverlag
16,00