Advances in General and Cellular Pharmacology

1 Cardiac Cellular Pharmacology: Automaticity in Cardiac Muscle—Its Alteration by Physical and Chemical Influences.- I. Automaticity in Heart Muscle.- II. Characteristics of the “Resting” Membrane in Cardiac Cells.- III. Membrane Currents which Underlie Spontaneous Phase 4 Depolarization in Automatic Cardiac Cells.- IV. Modification of Automaticity by Physical and Chemical Agents.- V. Summary.- References.- 2 Actions of Opiates and Their Antagonists on Cholinergic Transmission in the Guinea Pig Ileum.- I. Introduction.- II. Mechanism of Contractions Induced by Electrical Stimulation.- III. Procedure for Setting Up the Ileum.- IV. Determination of Opiate Potency.- V. Site of Blocking Action of Drugs.- VI. Activities of Opiates and Antagonists on the Ileum.- VII. Actions of Inhibitors of Prostaglandin Synthesis.- VIII. Mechanism of Opiate Effects on Cholinergic Transmission: Relation to the Prostaglandin System.- References.- 3 Pharmacology of Heart Cells During Ontogenesis.- I. Introduction.- II. Experimental Methods.- III. Cardiac Development.- IV. Modification of Electrical and Mechanical Activity of Embryo Hearts Produced by Drugs.- V. Summary.- References.- 4 Analysis of Dose—Response Relationships.- I. Some Comments on General Pharmacology.- II. Empirical Examination of Dose-Response Curves.- III. Kinetic Analysis of Dose-Response Curves.- IV. Mechanistic Analysis of the Dose-Response Relationship.- V. Summary.- References.- 5 Cellular Pharmacology of Ganglionic Transmission.- I. General Characteristics of Autonomic Ganglia.- II. Postsynaptic Receptor Sites.- III. Presynaptic Receptor Sites.- IV. Transmitter Liberation.- V. Some Specific Physiopharmacologic Characteristics of Postsynaptic Neuron Membrane.- References.