Handbook of Experimental Pharmacology / Biochemical Pharmacology of Blood and Blood-Forming Organs

This volume offers an overview of current knowledge about how haematopoiesis is fundamentally controlled by haematopoietin and other haematopoietic factors. Recent advances covered include the purification of erythropoietin and colony stimulating factor and work on interleukins.

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How is haematopoiesis fundamentally controlled by haematopoietin and other haematopoietic growth factors? This volume gives an overview of our present knowledge and focuses in particular on recent advances. These include, for example, the purification of erythropoietin and colony stimulating factor and the availability and function of interleukins. Another aspect is the effect of toxic environmental agents on blood and blood-forming organs - how they suppress erythropoiesis, myelopoiesis and megokaryocytopoiesis as well as major haematopoietic lineages stimulated by erythropoietin, macrophage colony stimulating factor, granulocyte colony stimulating factor, interleukin 1-alpha and 1-beta, 2, 3, 4, 5, 6 and 7. The contents are completed by chapters dealing with the application of growth factors in the treatment of anemia of end stage renal disease. An up-to-date overview of the chemotherapy of leukemia is also given.