Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Group 2 Innate Lymphoid Cells in the Lung
Li Yin Drake and Hirohito Kita
The Ubiquitin System in Immune Regulation
Yoon Park, Hyung-seung Jin, Daisuke Aki, Jeeho Lee and Yun-Cai Liu
How Immunoglobulin G Antibodies Kill Target Cells: Revisiting an Old Paradigm
Markus Biburger, Anja Lux and Falk Nimmerjahn
A Transendocytosis Perspective on the CD28/CTLA-4 Pathway
Blagoje Soskic, Omar S. Qureshi, Tiezheng Hou and David M. Sansom
How to Trigger a Killer – Modulation of Natural Killer Cell Reactivity on Many Levels
Carsten Watzl
Roles for Helper T Cell Lineage-Specifying Transcription Factors in Cellular Specialization
Amy S. Weinmann
MHC Class I Recognition by Monocyte/Macrophage-Specific Receptors
Ryotaro Yoshida
Regulation of Regulatory T Cells: Epigenetics and Plasticity
Masahiro Okada, Sana Hibino, Kazue Someya  and Akihiko Yoshmura