Bile Acids and Hepatobiliary Diseases - Basic Research and Clinical Application

Adolf-Windaus-Award 1996; W. Gerok. Adolf-Windaus-Prize Lecture: Bile Acid Transport Systems as Pharmaceutical Targets; W. Kramer. I: Bile Acid Biosynthesis and Metabolism. 1. Determinants of Biliary Bile Acid Composition in Mammals: Influence of Age and Gender; M. Gavrilkina, et al. 2. Identification of a Unique Inborn Error in Bile Acid Conjugation Involving a Deficiency in Amidation; K.D.R. Setchell, et al. 3. Regulation of Sterol 27-Hydroxylase and Its Role in the Regulation of 'acidic' Pathway of Bile Acid Synthesis; Z.R. Vlahcevic, et al. 4. Sterol 12alpha-hydroxylase: a Key Cytochrome P-450 in Bile Acid Synthesis. Cloning and Expression of the Rabbit Enzyme; G. Eggertsen, et al. 5. Stereochemistry of Peroxisomal Side-Chain Degradation in Bile-Salt Biosynthesis; W. Dieminger, et al. 6. Does Cisapride Overcome the Effects of Octreotide on Intestinal Transit, Thereby Reducing the Proportion of Deoxycholic Acid in Bile and Serum? M.J. Vesey, et al. II: Hepatic Bile Acid Transport. 7. Regulation of Bile Acid Carrier Expression in Normal and Diseased Liver; P.J. Meier. 8. Regulation of the Organic Anion Transporting Polypeptide of Human Liver; G.A. Kullak-Ublick, et al. 9. Regulation of Bile Acid Transporters in Experimental Cholestasis; C. Gartung, J.L. Boyer. 10. Regulation of Hepatocyte Bile Salt Transporters by Endotoxin and Cytokines; R.M. Green, J.L. Gollan. 11. ATP-Binding Cassette Proteins and the Molecular Basis of Liver Cell Membrane Transport; N. Lomri, et al. 12. ATP-Dependent Transport of Dianionic Bile Salts by the Canalicular Isoform of the Multidrug Resistance Protein (MRP2/cMRP/cMOAT); D. Keppler, et al. 13. Cloning and Characterization of cMOAT, a Transporter for Divalent Anionic Bile Salts; C.C. Paulusma, et al. 14. Stimulation of Bile Acid Secretion by Tauroursodeoxycholate and Cell Swelling Involves Mitogen-Activated Protein Kinase; D. Haussinger, et al. III: Intestinal Bile Acid Transport. 15. The Molecular Genetics of Ileal Bile Acid Transport; P.A. Dawson, P. Oelkers. 16. Properties and Specificity of the Rabbit Ileal Na+/Bile Acid Cotransport System; W. Kramer, et al. 17. Regulation of the Sodium-Dependent Ileal Bile Acid Transporter in the Rat; R.T. Stravitz, et al. 18. Effect of Cholestasis on Ileal and Jejunal Absorption of Bile Acids in Rat; P. Sauer, et al. 19. Cloning and Characterization of a Regulon Involved in Bile Acid Transport and 7-Dehydroxylation in an Intestinal Eubacterium Species; D.H. Mallonee, P.B. Hylemon. IV: Biological Actions of Bile Acids. 20. Effects of Bile Acids on Bile Secretion; J.L. Boyer. 21. Modulation of Hepatocellular Signaling by Bile Acids; U. Beuers, et al. 22. Ursodeoxycholate Activates Ca2+-dependent Cl- currents in a Human Biliary Cell Line; R. Roman, et al. 23. Bile Salt Stimulation of Biliary Phospholipid Secretion; J.M. Crawford. 24. Organic Anions Do Not Impair Bile Salt Micellization in In Vitro Model Bile Systems: Implications for the Mechanism of Organic Anion-Induced Inhibition of Biliary Lipid Secretion In Vivo; H.J. Verkade, et al. 25. Antioxidant Properties of Bile Acids Evaluated with Enhanced Chemiluminescent Assay: A Possible Physiological Role; A. Roda, et al. 26. Bile Salt Induces Alterations in Bilayer Permeability: Insights Into Cytoprotection and Cytotoxicity; A. Albalak, et al. 27. Effector Proteases in Bile Salt-Induced Hepatocyte Apoptosis; L.R. Roberts, et al. 28. Borderline Pathology in mdr2(-l-) Rescue Mice: A New Model to Study Non-Suppurative Cholangitis; M. de Vree, et al. 29. Effects of Deoxycholic Acid on Cholesterol and Bile Acid Metabolism in Human Liver; C. Einarsson, et al. 30. Bile Acids Modulate the Interferon Signalling Pathway; P. Podevin, et al. 31. Obstructive Cholestasis Inhibits the Rate of Cholesterol 7a-Hydroxylation in Humans In Vivo; M. Bertolotti, et al. V: Bile Acids in Therapy. 32. Multi-Drug Treatment for Primary Biliary Cirrhosis: Is More Better?; B.J.F. van Hoogstraten, et al. 33. Ursodeoxycholic Acid in Combination with Prednisolone or Budenoside in the Therapy of Primary Biliary Cirrhosis; U. Leuschner, et al. 34. Bile Acid Synthesis, Metabolism and Secretion in Primary Biliary Cirrhosis Before and After Steroid and Colchicine Treatment; E. Roda, et al. 35. Medical Treatment of Primary Sclerosing Cholangitis: On the Role of Ursodeoxycholic Acid; A. Stiehl, et al. 36. Ursodeoxycholic Acid in the Treatment of Cholestasis of Pregnancy; J. Palma, et al. 37. Clinical Outcome of Long-Term Treatment of Ursodeoxycholic Acid in Patients with Cystic Fibrosis-Associated Liver Disease; C. Colombo, et al.