Chemical Biology of Nucleic Acids (eBook)

RNA as Major Components in Chemical Evolvable Systems - Peter StrazewskiHow the Early Genetic Code Was Established? -Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems - Kimitsuna Watanabe and Shin-ichi YokoboriIsomerization of RNA Phosphodiester Linkages – Harri LönnbergEffects of Ionic Liquid and Liposomes on the Structure, Stability, and Function of Nucleic Acids - Naoki SugimotoOxidative Damage on RNA Nucleobases - Pascal A. Küpfer and Christian J. LeumannUse of FRET to Study Dynamics of DNA Replication - Philip Nevin and Penny J. BeuningDesign, Characterization, and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds – Noriaki Minakawa and Akira MatsudaCreation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies - Michiko Kimoto and Ichiro HiraoFlexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids - Sarah C. Zimmermann and Katherine L. Seley-RadtkeSequence Selective Recognition of Double-Stranded RNA – Eriks RoznersDetermining Transient Nucleic Acid Structures by NMR – Jeetender ChughDiastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties - Qing Li, Oleksandr Plashkevych, Ram Shankar Upadhayaya, Sachin Gangadhar Deshpande, Andras Földesi, and Jyoti ChattopadhyayaChallenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms - Ramon Eritja, Montserrat Terrazas, Santiago Grijalvo, Anna Aviñó, Adele Alagia, Sónia Pérez-Rentero, and Juan Carlos MoralesProgress in Chemically Modified Nucleic Acid Aptamers - Masayasu KuwaharaAptamers as Molecular Smugglers - Eileen Magbanua and Ulrich HahnBiochemical Aspects of Subcellular RNA Transport and Localization - Diana Bauermeister, Maike Claußen, and Tomas PielerSmall Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications - Wendy W.K. Mok, Simon A. McManus, and Yingfu LiTowards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology - Anders Hauge Okholm, David Schaffert, and Jørgen KjemsTargeted Editing of Therapeutic Genes using DNA-Based Transcriptional Activators: Scope and Challenges - Ganesh N. Pandian and Hiroshi SugiyamaInteraction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression – Irine Khutsishvili, Sarah E. Johnson, Calliste Reiling, Istok Prislan, Hui-Ting Lee, and Luis A. MarkySite Directed Spin Labelling of RNA for Distance Measurements by EPR - Joachim W. Engels, Christian Grünewald, and Lena WickeChemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells - Daniela Schulz and Andrea RentmeisterMetal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches - Joseph E. Wedekind, Joseph A. Liberman, Jermaine L. Jenkins, and Mohammad SalimDNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics - Yogini P. Bhavsar-Jog, Samantha M. Reilly, and Randy M. WadkinsPeptides Targeting G-Quadruplex Structures - Kenji Usui and Arisa OkadaSynthesis of Site-Specifically Modified Long-Mer RNAs – Darko Balke, Jennifer Frommer, Nico Rublack, Danilo Springstubbe, Bettina Appel, and Sabine MüllerSynthesis and Exon-Skipping Activity of Chemically-Modified RNAs - Yoshiaki Masaki, Takeshi Yamada, Hisao Saneyoshi, Akihiro Ohkubo, Kohji Seio, and Mitsuo SekinemRNA and snRNA Cap Analogs: Synthesis and Applications - Janusz Stepinski and Edward DarzynkiewiczInnovative Chemistry for Synthesis of Regular RNA, 5’-Triphosphate RNA or 5’-Capped RNA – Yann Thillier, François Morvan, Jean-Jacques Vasseur and Françoise Debart.