Biological Effects of 224Ra

Benefit and Risk of Therapeutic Application Proceedings of the Second Symposium at Neuherberg/München, September 20–21, 1976

W.A. Müller, H.G. Ebert (Herausgeber)

Buch | Softcover

235 Seiten

2011 | Softcover reprint of the original 1st ed. 1978
Springer (Verlag)
978-94-009-9730-1 (ISBN)

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Under an association contract linking the Co~ission of the European Communities and the Gesellschaft fUr Strahlen- und Umweltforschung mbH, a research programme on the patho- genesis of somatic radiation damage has been under way for a number of years. Experimental research on long-term radiation effects following the incorporation of bone-seeking radionuclides and an epidemiological study of the conse- quences for patients treated with 224Ra for therapeutical reasons have been among the main features of the work. The research carried out on tumor induction in the low dose range and for low dose rates is particularly important as regards assessing the radiation hazard to man. The second Symposium on the biological effects of 224Ra, held at Neuherberg, provided a welcome opportunity to take stock of what has been achieved so far and to discuss the own research efforts in an international setting. The dis- cussions focussed on two topical aspects of radiation protection. One aspect was the long-term effects of high-LET ionizing radiations on man and the quantitative data involved in risk assessment at low doses.
The epidemiological studies and experimental research carried out under the association contract should provide facts and figures for an objective assessment of the radiation hazards from incorporated radio- nuclides, which is one of the fundamental and controversial problems of the nuclear energy debate.

Session I.- Zur Klinik der ankylosierenden Spondylitis (Morbus Bechterew).- Pathology and radiology of ankylosing spondylitis.- Session II.- Indication for 224Ra-therapy in ankylosing spondylitis.- Problems and results of a new follow-up study - 224Ra in adult ankylosing spondylitis patients.- Addendum to the previous paper: Risk to bone from present 224Ra therapy.- Quality control in the production process and purity of 224Ra for injection.- Therapeutical results in a follow-up study 224Ra-therapy of ankylosing spondylitis.- X-ray therapy in the treatment of ankylosing spondylitis.- Session III.- Radiosynoviorthesis: Local treatment of rheumatoid arthritis.- Comparison of the efficacy of 224and other radio-isotopes in the treatment of rheumatoid arthritis.- Experimental data on the injection of 224Ra into the knee-joint of rats and rabbits.- Intravenous injection of 224Ra in Morbus Paget.- Session IV.- Clinical experiences concerning late effects and risks of 224Ra.- Osteogenic sarcomas in mice after 224Ra or 226Ra administrations.- Biological effects of 224Ra and 226Ra and their relative radiotoxicity in mice.- The dependence of late effects in mice on the temporal distribution of skeletal ?-doses from 224Ra and 227Th.- Histopathology of early effects of 224Ra on bone tissue.- Expression of type C RNA virus particles in 224Ra-induced osteosarcomas.- Session V.- Bone sarcoma risks to man from 224Ra 226Ra and 239Pu.- Problems in radiological protection involving ?-emitters in bone.- A model for the induction of bone cancer by 224Ra.- Methodological aspect of epidemio-logical inquiries in clinical radio- biology.- Notre experience du 224Ra dans le traitement de la spondylarthrite ankylosante.- Round Table Discussion I Moderator: C.W. Mays Risk evaluation of ankylosingspondylitis therapy.- Round Table Discussion II Moderator: W. Koch Clinical results of ankylosing spondylitis therapy.- R.H. Mole Concluding remarks.- List of participants.

Zusatzinfo	235 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Nuklearmedizin
ISBN-10	94-009-9730-2 / 9400997302
ISBN-13	978-94-009-9730-1 / 9789400997301
Zustand	Neuware