The Protective Arm of the Renin Angiotensin System (RAS)

Part I: The AT2 Receptor

Introduction

The AT2 receptor: from enigma to therapeutic target

AT2 receptor detection by selective ligands

Basic mechanisms and signaling

Animal models with a genetic alteration of AT2 expression

AT2 signaling: resolved and unresolved

AT1-AT2 crosstalk

(Patho)-physiological effects of AT2R stimulation

AT2R in Myocardial infarction and congestive heart failure

AT2R, vascular effects, blood pressure effects                             

AT2R in neuroprotection and -regeneration

AT2R and cognitive function

AT2R in kidney disease

AT2R and natriuresis

AT2R and vascular remodeling

AT2R and inflammation

AT2R, ATIP and cancer

AT2R and sympathetic outflow

Metabolic effects of AT2R stimulation

Gender differences in AT2R expression and actions

Future clinical application

Discovery of non-peptide selective AT2R agonists

Synthesis of peptide AT2 agonists

Potential future clinical indications for AT2-agonists

Part II: MAS Receptor / Ang(1-7) / ACE-2:

Introduction

The Mas Story

Basic mechanisms and signaling

Animal models with a genetic alteration of ACE2/MAS

MAS signaling: resolved and unresolved

MAS dimerisation and MAS/AT2 crosstalk

Basic aspects of ACE-2 regulation and function

(Patho)-physiological effects of MAS stimulation

MAS in Myocardial infarction and congestive heart failure

MAS, vascular effects, blood pressure effects                             

MAS in neuroprotection and -regeneration

MAS and cognitive function

MAS in the kidney