Asfar Azmi, PhD, is an Assistant Professor at the Department of Oncology, Wayne State University. He has more than a decade of research experience in the area of cancer biology and drug discovery. Dr. Azmi's lab has made significant pre-clinical discoveries in advanced animal tumor models that helped the clinical development of new cancer drugs. Dr. Azmi has considerable experience in the area of early phase clinical research. Several agents developed by his team have gone into Phase II clinical studies. He has published more than 100 cancer research articles and has edited three additional books, among which there are the Elsevier publications Molecular Diagnostics and Treatment of Pancreatic Cancer as well as Conquering Ras. He is the recipient of numerous young investigator awards from premier scientific bodies. The National Institute of Health and pharmaceutical industry have continuously funded his lab.
Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. - Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales- Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas helping researchers in pancreatic cancer drug discovery- Summarizes many relevant computational and clinical references from fast-evolving literature- Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature
Contributors
AmirAbdollahi
German Cancer Consortium (DKTK), Heidelberg, Germany
Molecular & Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), University of Heidelberg Medical School and National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany
Baltazar D.Aguda, DiseasePathways LLC, Bethesda, MD, USA
ShadanAli, Department of Oncology, Karmanos Cancer Institute, Detroit, MI, USA
Osama M.Alian, Department of Oncology, Karmanos Cancer Institute, Detroit, MI, USA
Laufey T.Amundadottir, Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Asfar S.Azmi, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
Ginny F.Bao, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
Oliver F.Bathe, Departments of Surgery and Oncology, University of Calgary, Calgary, AB, Canada
Charles E.Birse, Department of Protein Therapeutics, Celera, Rockville, MD, USA; Celera, Alameda, CA, USA
Teresa A.Brentnall, Department of Medicine, University of Washington, Seattle, WA, USA
RuChen, Department of Medicine, University of Washington, Seattle, WA, USA
SaraChiblak
German Cancer Consortium (DKTK), Heidelberg, Germany
Molecular & Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), University of Heidelberg Medical School and National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany
EdmundClarke, Computer Science Department, Carnegie Mellon University, Pittsburgh, PA, USA
BrunoDomon, Department of Protein Therapeutics, Celera, Rockville, MD, USA; Luxembourg Clinical Proteomics Center, CRP-Sante, Luxembourg
NiccolaFunel, Department of Surgical, Molecular and Medical Pathology, University of Pisa, Pisa, Italy
JiankunGao, Department of Basic Medical Sciences, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China
HaijunGong, Department of Mathematics and Computer Science, Saint Louis University, St. Louis, MO, USA
RobertGrützmann, Department of General, Thoracic, and Vascular Surgery, University Hospital “Carl Gustav Carus”, Dresden University of Technology, Dresden, Germany
TaoHe, Department of Protein Therapeutics, Celera, Rockville, MD, USA; Pfizer, Cambridge, MA, USA
JasonHoskins, Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Sun-IlHwang, Proteomics and Mass Spectrometry Research Laboratory, Carolinas HealthCare System, Charlotte, NC, USA
JinpingJia, Laboratory ofTranslational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Amin I.Kassis, Department of Radiology, Harvard Medical School, Boston, MA, USA
Jin-GyunLee, Proteomics and Mass Spectrometry Research Laboratory, Carolinas HealthCare System, Charlotte, NC, USA
Candy N.Lee, Department of Protein Therapeutics, Celera, Rockville, MD, USA; Pfizer, South San Francisco, CA, USA
Lance A.Liotta, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA
Kenneth E.Lipson, FibroGen, Inc., San Francisco, CA, USA
IanMcCaffrey, Department of Protein Therapeutics, Celera, Rockville, MD, USA; Genentech, South San Francisco, CA, USA
Kimberly Q.McKinney, Proteomics and Mass Spectrometry Research Laboratory, Carolinas HealthCare System, Charlotte, NC, USA
KatherineMcKinnon, Department of Protein Therapeutics, Celera, Rockville, MD, USA; NCI, Bethesda, MD, USA
LucioMiele, University of Mississippi Cancer Institute, Jackson, MS, USA
Ramzi M.Mohammad, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA; Hamad Medical Corporation, Doha, Qatar
Paul A.Moore, Department of Protein Therapeutics, Celera, Rockville, MD, USA; MacroGenics Inc., Rockville, MD, USA
IrfanaMuqbil, Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, UP, India
ShengPan, Department of Medicine, University of Washington, Seattle, WA, USA
Emanuel F.PetricoinIII., Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA
Philip A.Philip, Department of Oncology, Karmanos Cancer Institute, Detroit, MI, USA
MariaelenaPierobon, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA
ChristianPilarsky, Department of Visceral-, Thoracic- and Vascular Surgery, Medizinische Universität Carl Gustav Carus, TU Dresden, Dresden, Germany
PavelPospisil, Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
Francisco X.Real, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Steven M.Ruben, Department of Protein Therapeutics, Celera, Rockville, MD, USA
Enrique Carrillo-deSanta Pau, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Fazlul H.Sarkar, Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI,...
Erscheint lt. Verlag | 14.4.2014 |
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Sprache | englisch |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie |
Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie | |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
ISBN-10 | 0-12-407946-6 / 0124079466 |
ISBN-13 | 978-0-12-407946-5 / 9780124079465 |
Haben Sie eine Frage zum Produkt? |
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