Solid Organ Transplantation in Infants and Children

Stephen P. Dunn, MD Chair, AI Dupont Hospital for Children, Department of Surgery Professor of Surgery, Jefferson Medical College, Wilmington, DE, USA.

S olid organ transplantation in infants and children: Through the looking glass.- Key differences in recipient characteristics in infants and children.- The Pediatrician and the care of the infant or child before and after solid organ transplantation.- Solid organ transplantation in the pediatric patient: the regulatory environment and it's requirements.- Evaluation and listing for transplant of the infant or child with end organ failure.- Maintenance of the infant or child with end organ failure.- Growth and development with end organ failure.- Anesthetic considerations for the child undergoing transplantation.- Intensive care of the child after solid organ transplantation.- Pathology of transplanted solid organs.- Immunologic responses of the child to short and long term immunosuppression.- Standard Immunosuppression.- Standard maintenance protocols: Medication, follow up visits, immunizations, sick child calls etc.- Immunosuppressive medication withdrawal.- Health related quality of life.- Late complications.- Progressive allograft injury and chronic rejection.- Nonadherence.- Retransplantation: challenges and strategies.- Transition to the adult care paradigm.- Growing up after a transplant: the child's perspective.- Raising a child after a transplant: the parent's perspective.- Continuous improvement in solid organ transplantation in infants and children.- The causes of kidney failure and timing of transplant.- The urine reservoir: evaluation and transplant strategies.- Technical aspects of kidney transplantation in the child.- Living donor kidney transplantation.- Salvage procedures for technical complications after kidney transplantation.- The causes of liver failure and timing of transplant.- Acute hepatic failure: Diagnosis, support and transplantation.- Technical aspects of liver transplantation.- Live donor liver transplantation: pediatric considerations.- Salvage procedures for technical complications after liver transplantation.- Causes of intestinal.- Technical aspects of intestinal transplantation.- Post transplant feeding regimens and monitoring paradigms.- Salvage procedures for technical complications after intestinal transplantation.- Living donor intestinal transplantation.- Causes of cardiac failure and timing of transplant.- Cardiac support devices and their use in infants and children in the overall strategy of cardiac transplantation.- Technical aspects of cardiac transplantation.- Salvage procedures for technical complications of cardiac transplantation.- Causes of lung failure in infants and children and timing of transplant.- Single or double lung transplantation: How to decide.- Combined heart-lung transplantation.- Technical aspects of lung and heart lung transplantation.- Salvage operations for technical complications after lung or heart-lung transplantation.