Alterations of Excitation-Contraction Coupling in the Failing Human Heart

Ca transport during contraction and relaxation in mammalian ventricular muscle.- Sites of regulatory interaction between calcium ATPases and phospholamban.- The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility.- Phosphorylation and regulation of the Ca2+-pumping ATPase in cardiac sarcoplasmic reticulum by calcium/calmodulin-dependent protein kinase.- Site-specific phosphorylation of a phospholamban peptide by cyclic nucleotide- and Ca2+/calmodulin-dependent protein kinases of cardiac sarcoplasmic reticulum.- Sodium-calcium exchange: Recent advanves.- Expression and function of the cardiac Na+/Ca2+ exchanger in postnatal development of the rat, in experimental-induced cardiac hypertrophy, and in the failing human heart.- Plasma membrane calcium pump: structure, function, and relationships.- Regulation of mRNA-expression of the sarcolemmal calmodulin- dependent calcium pump in cardiac hypertrophy.- Molecular mechanisms regulating the myofilament response to Ca2+: Implications of mutations causal for familial hypertrophic cardiomyopathy.- Ca2+-dependent and Ca2+-independent regulation of contractility in isolated human myocardium.- Calcium handling proteins in the failing human heart.- Role of c AMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure.- Contributions of Ca2+-influx via the L-type Ca2+-current and Ca2+-release from the sarcoplasmic reticulum to [Ca2+]i-transients in human myocytes.- Molecular and cellular aspects of re-entrant arrhythmias.