Tendon Regeneration

Manuela E. Gomes is Associate Professor and Vice-President of the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Dr. Gomes is also on the Board of Directors of the Portuguese Associate Laboratory that gathers the Institute for Life and Health Sciences of the University of Minho and the 3B´s Research Group and was responsible for the implementation of the Quality Management System at the 3B’s. She is a board member of the Doctoral Program on Tissue Engineering Regenerative Medicine and Stem Cells and has been part of numerous European and national/regional projects as PI/member. She was awarded a Consolidator Grant and a PoC from the European Research Council that started in 2018 and 2022, respectively. She has edited 2 books, 1 encyclopedia, and is author of 43 book chapters, 226 scientific papers in journals with international peer-review, 9 patents and over 344 communications in international conferences. Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize. Márcia T. Rodrigues is an Assistant Researcher the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Her research is focused on strategies to study persistent inflammation cues and associated pathways that impair tissue healing and regeneration. Dr. Rodrigues has mentored and supervised several PhD, MSc, and BSc students. Currently, she supervises 1 PhD student and mentors 3 post-doctoral fellows. She has also been part of the scientific committee and organization of 8 international scientific events and acts as a peer reviewer in > 20 major international journals in the field. She is also a member of the Editorial Board of IJMS and editor of 2 special issues for IJMS and Adv Drug Deliv Rev (2022). Dr. Rodrigues co-edited one scientific book Tendon Regeneration (Elsevier), authored 13 book chapters, 1 Encyclopedia chapter, 48 papers in international refereed journals, 3 featured articles, and 4 corresponding author papers.

Preface Manuela E. Gomes, Marcia T. Rodrigues, Rui L. Reis

1. Tendon Physiology and Mechanical Behavior: Structure-Function Relationships 2. Tendon Resident Cells – Function and Features 3. Mechanobiology of Tendons

Section II – Pathologies and repair of tendons 4. Tendinopathies (I): Understanding Epidemiology, Pathology,  Healing and Treatment 5. Tendinopathies (II): Etiology, Pathology, and Healing of Tendon Injury and Disease

Section III- Tendon Regenerative Medicine approaches 6. Cell Based Approaches for Tendon Regeneration 7. GF Approaches in Tendon Stimulation

Section IV – Scaffolds-Based Approaches 8. Scaffold-Based Approaches (I): Engineering anisotropic 2D and 3D structures for tendon repair and regeneration 9. Scaffold-Based Approaches (II): Biological and synthetic based scaffolds for tendon regeneration

Section V – Tendon Tissue Engineering 10. Tendon TE: Hierarchical and Biomimetic Structures to Support the Regeneration of Tendon Tissues 11. Tendon TE: Multifactoral Tendon Tissue Engineering Strategies 12. Tendon TE: Combined Tissue Engineering Approach for the Regeneration of Tendons 13. Tendon TE: Biomaterial scaffolds for tendon tissue engineering 14. Pre-Clinical models for Tendon Translational Therapies 15. Scaffold design for integrative tendon-bone repair