Selective Estrogen Receptor Modulators

I Molecular Mechanisms of Estrogen Receptor Function.- 1 Structure and Function of the Estrogen Receptor.- 2 Ligand-Induced Conformational Changes in Estrogen Receptors-? and -?.- 3 Expression and Function of Estrogen Receptors-? and -?.- 4 SERM Modulation of Gene Expression: Role of Coactivators and Corepressors.- 5 Crosstalk Between Estrogen Receptors and Growth Factor Signaling.- II Tissue-Specific Effects of Estrogens and SERMs.- 6 Direct Estrogen Effects on the Cardiovascular System.- 7 Estrogens and the Brain: Implications for the Treatment of Postmenopausal Women.- III Preclinical Studies.- 8 Insights into the Molecular Mechanism of SERMs Through New Laboratory Models.- 9 Third- and Fourth-Generation SERMs.- IV Organ Specific Effects of Estrogens and SERMs.- 10 SERMs’ Effect on the Neuroendocrine System and the Reproductive Organs.- 11 Epidemiology of Cardiovascular Disease in Women: Role of Estrogens.- 12 SERMs Effects on Cardiovascular Risk Factors and Disease.- 13 Estrogen and the Skeleton.- 14 Effects of SERMs on Bone in Clinical Studies.- 15 Estrogens and SERMs: Clinical Aspects of Cognition with Aging and Neurodegenerative Disorders.- V SERMs and Endocrine Dependent Tumors.- 16 SERMs and Breast Cancer Prevention.- 17 SERMs in Postmenopausal Women’s Health.- VI Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy.- 18 Menopause Therapy: An Individualized Approach.- 19 Alternatives to Estrogen for Treatment of Menopause.- 20 Phytoestrogens in the Context of SERMs.