Drugs Affecting Leukotrienes and Other Eicosanoid Pathways

Measurement of Thromboxane Production in vivo: Metabolic and Analytical Aspects.- High Pressure Liquid Chromatography-125J-Ria, a Sensitive and Specific Prostaglandin Assay.- Enzyme Immunoassays of Icosanoids Using Acetylcholinesterase.- Syntheses and Biological Effects of Leukotrienes and Analogs.- Pharmacologic Modulation of Leukotriene Biosynthesis by Incorporation of Alternative Unsaturated Fatty Acids (20:5 and 22:6).- Studies with Inhibitors of Leukotriene Biosynthesis with Special Reference to Piriprost (U-60,257).- Pulmonary and Vascular Effects of Leukotrienes; Involvement in Asthma and Inflammation.- Modulation of the Release of Leukotrienes and Prostaglandins and of their Functional Effects in Human and Guinea-Pig Lung Parenchyma.- Comparative Effects of Leukotrienes in Respiratory Tissue of Various Species.- The Effects of Low-Dose Aspirin and Selective Inhibitors of Thromboxane-Synthase on Eicosanoid Production in Man.- Manipulation of Pro-and Antiaggregating Prostaglandins: New Antithrombotic Strategies.- Flavonoids — Lipoxygenases — Platelet Aggregation.- Transformation of 15-Hydroperoxyeicosapentaenoic Acid Into Mono- and Dihydroxyeicosapentaenoic Acids by Human Platelets.- Metabolism of Arachidonic Acid by 12- and 15-Lipoxygenases in Human Platelets and Polymorphonuclear Leukocytes.- Epoxidation of Arachidonic Acid and Prostacyclin in the Kidney.- The Effect of 9 ? -Fluorohydrocortisone on the Urinary Excretion of 6-Keto-PGF1 in Man.- Prostacyclin in Therapy of Vascular Disease.- LTC4 Induces Hyperreactivity of the Isolated Vascular Tissue to Histamine, Serotonin and Norepinephrine.- Evidence for a Thromboxane Antagonist in Selected in vitro and in vivo Systems.- Precursor-Product. Relationship in Vascular Eicosanoid Formation after Manipulation ofDietary Fatty Acids in Experimental Animals.- Formation of Leukotrienes and other Eicosanoids in the Gastrointestinal Tract and Effect of Drugs.- Role of Eicosanoids in the Pathogenesis of Inflammatory Bowel Diseases.- Inhibition of 5’Lipoxygenase: Relevance to Inflammation.- The Role of Glucocorticoid-Induced Phospholipase Inhibitory Proteins.- Formation and Oxidative Degradation of Leukotrienes by Eosinophils and Neutrophils.- Eicosanoids and Cancer.- Stimulated Human Colonic Synthesis of Arachidonate Lipoxygenase and Cyclo-Oxygenase Products by Laxatives.- Correlation Between K+ Fluxes and the Arachidonic Acid Cascade in Human Leukocyte Stimulated with A-23187 or Melittin.