Fundamentals of Asymmetric Synthesis

G. L. David Krupadanam

Introduction. Terms, Definitions and Concepts in Asymmetric Synthesis. Achiral and Chiral Molecules and Their Properties. Prochirality. Enantioselective and Diastereoselective Synthesis. Methods for Monitoring Enantioselective and Diastereoselective Synthesis. Methods for Inducing Asymmetry. Chiral Substrate Controlled Asymmetric Reactions: Diastereoselection in acyclic systems. Chiral auxiliary controlled asymmetric reactions—Asymmetric α-alkylations. Chiral Stoichiometric Reagent Controlled Asymmetric Synthesis: Chiral Boron Reagents. Chiral Catalyst Mediated Asymmetric Reactions: Enzymes. Chiral Organometallic Catalysed Asymmetric Reactions: Sharpless Asymmetric Epoxidations, Dihydroxylations and Aminohydroxylations. Chiral Organometallic Catalysed Asymmetric Reactions. Organocatalysts in Asymmetric Synthesis—Chiral Additive Mediated Reactions. Asymmetric Aldol Reaction. Asymmetric Diels–Alder reactions. Stereoselective Synthesis and Stereospecific Synthesis. Index.