Dialysis Therapy

Dr. Richard E. Fine received his Bachelor's and PhD degrees in Biochemistry from University of California at Berkeley and Brandeis University respectively. He then was a postdoctoral fellow in the laboratory of Francis Crick and Sydney Brenner at the Laboratory of Molecular Biology in Cambridge, U.K. During this period he and his colleague, Dennis Bray provided the first evidence for actin in growing neurons. Dr. Fine became an Assistant Professor of Physiology and Biochemistry at Boston University School of Medicine and demonstrated the existence of actin regulatory molecules, tropomyosin and troponin C in growing neurons, and he subsequently became interested in the role of clathrin coated vesicles in endocytic and exocytic processes in neurons and in other tissues. He also isolated and characterized vasopressin receptors, demonstrated for the first time that a large molecular, transferrin, can cross the blood brain barrier. Our lab in collaboration with Dr. Ken Kosik were the first to show that an antisense oligonucleotide can be used in vivo to block the synthesis of a single protein. Using the rabbit retina we were able to show that an antisense nucleotide against the kinesin mRNA can block the critical role of kinesin in the transport of synaptic vesicles, neuropeptide containing vesicles and vesicles destined for the plasma membrane. In recent years Dr. Fine's laboratory has focused on the role of the amyloid beta peptide in Alzheimer's disease especially in brain capillary endothelium. Also he has recently focused on the role of a mutant protein VPS35, a component of the retromer in Parkinson's and Alzheimer's diseases. During his career he has received over $25,000,000 in grant funding, have served on both NIH and VA review panels and authored or co-authored over 100 research papers.

1. DEMOGRAPHICS Demographics of the ESRD Population 2. VASCULAR ACCESS FOR HEMODIALYSIS Temporary Vascular Access for Hemodialysis Monitoring for Vascular Access Failure Vascular Access for Hemodialysis Major Complications from Vascular Access for Chronic Hemodialysis Dialysis Access Recirculation 3. PERITONEAL ACCESS DEVICES Peritoneal Access Devices and Placement Techniques Complications of Acute Peritoneal Catheter Insertion 4. MECHANICAL ASPECTS OF DIALYSIS Water Treatment for In-Center Hemodialysis, Including Verification of Water Quality and Disinfection Single-Patient Hemodialysis Machines Single-Needle Dialysis Safety Monitors in Hemodialysis Management of Anticoagulation for Hemodialysis Home Preparation and Installation for Home Hemodialysis Peritoneal Dialysis Cyclers and Other Mechanical Devices 5. DIALYZERS Technical and Functional Considerations in Choosing Dialyzers Biocompatibility of Dialysis Membranes 6. KINETIC MODELING IN HEMODIALYSIS Urea Kinetic Modeling to Guide Hemodialysis Therapy in Adults Simplified Formulas for Monitoring Hemodialysis Adequacy 7. IMPROVING OUTCOMES IN DIALYSIS PATIENTS Quality Improvement Initiation of Dialysis Therapy Daily Hemodialysis NKF-K/DOQI (DOQI): Key Recommendations 8. THE HEMODIALYSIS PROCEDURE Hemodialysis Orders Pre- and Post-hemodialysis Assessment Techniques of Needle Placement in Dialysis Access Technical Problems During Dialysis Isolated Ultrafiltration 9. COMPLICATIONS DURING HEMODIALYSIS Common Clinical Problems During Hemodialysis Hemodialysis-Associated Seizure Activity Arrythmias in Hemodialysis Patients Prevention and Therapeutic Management of Bleeding in Dialysis Patients Hemolysis During Hemodialysis 10. REUSE OF HEMODIALYZERS Methods and Complications of Dialyzer Reuse 11. ALTERNATIVE HEMODIALYTIC TECHNIQUES Clinical Application of High-Efficiency Hemodialysis Slow Continuous Renal Replacement Therapies: CAVH, CVVH, CAVHD, CVVHD REDY Sorbent Hemodialysis System 12. PERITONEAL DIALYSIS: CLINICAL PRACTICE Determination of CAPD and CCPD Prescriptions Tidal Peritoneal Dialysis Peritoneal Dialysis Solutions Lymphatics and Peritoneal Dialysis 13. PERITONEAL DIALYSIS: INFECTIOUS COMPLICATIONS Abnormalities of Host Defense Mechanisms During Peritoneal Dialysis Peritoneal Catheter Exit-Site and Tunnel Infections Peritonitis in Peritoneal Dialysis Patients 14. PERITONEAL DIALYSIS: NONINFECTIOUS COMPLICATIONS Apparently Inadequate Peritoneal Membrane Function for Solute Removal Ultrafiltration Failure and Sclerosing Encapsulating Peritonitis Hypotension in Peritoneal Dialysis Patients Abdominal Catastrophes, Peritoneal Eosinophilia, and Other Unusual Events in Peritoneal Dialysis Patients 15. PERITONEAL DIALYSIS: INTRA-ABDOMINAL PRESSURE-RELATED COMPLICATIONS Abdominal Hernias in CAPD Dialysate Leaks Hydrothorax and Peritoneal Dialysis 16. ACID-BASE HOMEOSTASIS Acid-Base Homeostasis in Dialysis 17. NUTRITIONAL MANAGEMENT OF DIALYSIS PATIENTS Nutritional Therapy in Maintenance Hemodialysis Nutritional Management in Peritoneal Dialysis Parenteral Nutrition in Chronic Dialysis 18. GASTROINTESTINAL DISEASE Liver Disease in Dialysis Patients Ascites in Dialysis Patients 19. THE HIV-POSITIVE PATIENT Care of the HIV-Positive Dialysis Patient 20. ANEMIA AND EPOETIN USE Anemia in Patients wth End Stage Renal Disease Epoetin Use in Hemodialysis Patients Epoetin Use in Peritoneal Dialysis Patients Hypertension and Epoetin Use in Dialysis Patients Epoetin and Iron Deficiency Refractoriness to Recombinant Human Epoetin (r-HUEPO) Treatment Epoetin and Quality of Life Target Hemoglobin 21. CARDIOVASCULAR DISEASE Hypertension in Chronic Dialysis Patients Management of Ischemic Heart Disease, Heart Failure, and Pericarditis in Hemodialysis Patients 22. METABOLIC ABNORMALITIES Management of Hyperlipidemia in Chronic Dialysis Patients Abnormalities of Thyroid Function in Chronic Dialysis Patients Evaluation of Sexual Dysfunction in Dialysis Patients 23. NEUROLOGIC ASPECTS OF UREMIA Management of Uremic Peripheral Neuropathy Electroencephalography in the Evaluation of Neurologic Function in Renal Patients Impact of Anemia and Its Correction on Brain Function 24. UREMIC OSTEODYSTROPHY Differential Diagnosis of Renal Osteodystrophy Phosphorus Binders Use of Vitamin D Sterols in ESRD Patients Aluminum-Related Bone Disease in Dialysis Patients Management of Aluminum Toxicity Parathyroidectomy 25. DIALYSIS AMYLOIDOSIS Dialysis Amyloidosis 26. ACQUIRED CYSTIC KIDNEY DISEASE Acquired Cystic Kidney Disease 27. DIABETES Hemodialysis for End-Stage Diabetic Nephropathy Intraperitoneal Insulin in Diabetic Patients on Peritoneal Dialysis 28. DRUG USE IN UREMIA Principles of Drug Usage in Dialysis Patients 29. REHABILITATION AND PSYCHOSOCIAL ISSUES Endurance Exercise Training in Hemodialysis Patients Psychosocial Rehabilitation of Adult Dialysis Patients Ethical Considerations in the Care of Dialysis Patients 30. PEDIATRIC DIALYSIS Vascular Access in Children Microsurgical Techniques in Hemodialysis Vascular Access Surgery Infant Hemodialysis Urea Kinetic Modeling to Prescribe Hemodialysis in Children Anticoagulation in Pediatric Hemodialysis Peritoneal Catheter Placement in Children Peritoneal Dialysis Orders in Children Nutritional Management of Children on Peritoneal Dialysis Infant and Neonatal Peritoneal Dialysis Dialysis in Inborn Errors of Metabolism Psychosocial Adjustment and Treatment of Children and Adolescents with ESRD Growth in Children with ESRD Adequacy of Peritoneal Dialysis in Pediatric Patients PET in Pediatric Patients CAVH/CVVH in Pediatric Patients 31. SURGERY Surgery in ESRD Patients 32. THE PREGNANT PATIENT Pregnancy in Women on Dialysis 33. DRUG OVERDOSE Use of Dialytic Techniques for Drug Overdose