Dermal and Ocular Toxicology

David W. Hobson

Comparative Anatomy, Physiology, and Biochemistry of Mammalian Skin. Pathological Processes of Skin Damage Related to Toxicant Exposure. Considerations in the Design and Conduct of Subchronic and Chronic Dermal Exposure Studies With Chemicals. Evaluation of the Dermal Irritancy of Chemicals. Dermal Hypersensitivity: Immunologic Principals and Current Methods of Assessment. Cutaneous Photosensitization. Principles of Skin Permeability Relevant to Chemical Exposure. In Vivo Measurement of Dermal Absorption. In Vitro Assessment of Dermal Absorption. Isolated Perfused Skin Flap and Skin Grafting Techniques. In Vitro Alternative Methods for the Assessment of Dermatotoxicity. Use of Dermatotoxicologic Test Data in Product Development and in the Assessment of Chemical Hazards. Statistical Considerations for Ocular and Dermal Toxicology Studies. Comparative Anatomy and Physiology of the Mammalian Eye. Pathological Processes of the Eye Related to Chemical Exposure. Ocular Irritation Testing. Principles and Methods of Ocular Pharmacokinetic Evaluation. Alternative Methods for Assessing the Effects of Chemicals on the Eye. Preclinical Toxicity/Safety Considerations in the Development of Ophthalmic Drugs and Devices