Axonal Regeneration in the Mammalian Central Nervous System

1 Hypotheses Concerned with Regeneration in the Mammalian Central Nervous System.- 1.1 Introduction.- 1.2 Histopathological Response to Trauma.- 1.3 Successful Regeneration of Some Neurons in the Mammalian CNS.- 1.4 Hypotheses to Explain the Limited Regenerative Capacity of CNS Neurons.- 2 In Vivo Experimental Approaches to Hypotheses Concerned with Regeneration in the Mammalian CNS.- 2.1 Introduction.- 2.2 Submammalian Vertebrates.- 2.3 Developmental Events in Mammals.- 2.4 Morphological and Biochemical Assessment of Regeneration in Mammals.- 2.5 The Use of Transplants.- 2.6 Pharmacological Approaches.- 2.7 Conclusions.- 3 In Vitro Experimental Approaches to Hypotheses Concerned with Regeneration in the Mammalian CNS.- 3.1 Introduction.- 3.2 The Role of the Microenvironment - Neuronotrophic Factors.- 3.3 The Role of the Microenvironment - The Substrate and Substrate-Bound Neurite Promoting Factors.- 3.4 The Role of the Microenvironment - Humoral Neurite-Promoting Factors.- 3.5 The Role of the Microenvironment - The Non-neuronal Cells.- 4 Conclusions.- References.