Advances in Immunology
Academic Press Inc (Verlag)
978-0-12-800267-4 (ISBN)
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Regulation of Immunoglobulin Class Switch Recombination: Choreography of Non-Coding Transcription, Targeted DNA Deamination and Long-Range DNA RepairAllysia Matthews, Simin Zheng, Lauren DiMenna and Jayanta Chaudhuri
Two Forms of Adaptive Immunity in Vertebrates: Similarities and DifferencesMasanori Kasahara and Yoichi Sutoh
Recognition of Tumors by the Innate Immune System and Natural Killer CellsAssaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin and David H. Raulet
Signaling Circuits in Early B Cell Development Michael Reth and Peter Nielsen
Interleukin 10 Receptor Signaling: Master Regulator of Intestinal Mucosal Homeostasis in Mice and HumansDror S. Shouval, Jodie Ouahed, Amlan Biswas, Jeremy A. Goettel, Bruce Horwitz, Alexio M. Muise and Scott B. Snapper
Development of Mast Cells and Importance of their Tryptase and Chymase Serine Proteases in Inflammation and Wound HealingJeffrey Douaiher, Julien Succar, Luca Lancerotto, Michael F. Gurish, Dennis P. Orgill, Matthew J. Hamilton, Steven A. Krilis and Richard L. Stevens
Why does Somatic Hypermutation by AID Require Transcription of its Target Genes?Ursula Storb
Erscheint lt. Verlag | 10.4.2014 |
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Reihe/Serie | Advances in Immunology |
Verlagsort | San Diego |
Sprache | englisch |
Maße | 152 x 229 mm |
Gewicht | 540 g |
Themenwelt | Studium ► Querschnittsbereiche ► Infektiologie / Immunologie |
ISBN-10 | 0-12-800267-0 / 0128002670 |
ISBN-13 | 978-0-12-800267-4 / 9780128002674 |
Zustand | Neuware |
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