Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives (eBook)

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2013 | 2013
XI, 151 Seiten
Springer Tokyo (Verlag)
978-4-431-54445-6 (ISBN)

Lese- und Medienproben

Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives - Tsukasa Mizuhara
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The author successfully developed novel anti-HIV PD 404182 derivatives that exhibited submicromolar inhibitory activity against both HIV-1 and HIV-2. His thesis is in three parts. The first part expounds efficient methods for the synthesis of tricyclic heterocycles related to PD 404182 based on the sp2-carbon?heteroatom bond formations. Starting from arene or haloarene, C-O, C-N, or C-S bonds were formed by simply changing the reactants. These synthetic methods provide powerful approaches for the divergent preparation of pyrimido-benzoxazine, -quinazoline, or -benzothiazine derivatives. The second part explains SAR studies of PD 404182 for the development of anti-HIV agents. Through optimization studies of the central 1,3-thiazin-2-imine core, the benzene and cyclic amidine ring parts, 3-fold more potent inhibitors were obtained compared with the lead compound. The author also reveals by a time-of-drug-addition experiment that PD 404182 derivatives impaired HIV replication at the binding or fusion stage. The third part of the thesis elucidates the development of photoaffinity probes for the target identification of PD 404182. By the photolabeling experiment of HIV-1-infected H9 cells using these probes, the author detected proteins specifically bound to PD 404182. These new anti-HIV agents may be promising agents for anti-HIV therapy because their mechanisms of action differ from those of the currently approved anti-HIV agents.



Department of Chemistry

University of Massachusetts Amherst, USA

Ph. D. in Pharmaceutical Sciences

Graduate School of Pharmaceutical Sciences,

Kyoto University, Japan


The author successfully developed novel anti-HIV PD 404182 derivatives that exhibited submicromolar inhibitory activity against both HIV-1 and HIV-2. His thesis is in three parts. The first part expounds efficient methods for the synthesis of tricyclic heterocycles related to PD 404182 based on the sp2-carbon-heteroatom bond formations. Starting from arene or haloarene, C-O, C-N, or C-S bonds were formed by simply changing the reactants. These synthetic methods provide powerful approaches for the divergent preparation of pyrimido-benzoxazine, -quinazoline, or -benzothiazine derivatives. The second part explains SAR studies of PD 404182 for the development of anti-HIV agents. Through optimization studies of the central 1,3-thiazin-2-imine core, the benzene and cyclic amidine ring parts, 3-fold more potent inhibitors were obtained compared with the lead compound. The author also reveals by a time-of-drug-addition experiment that PD 404182 derivatives impaired HIV replication at the binding or fusion stage. The third part of the thesis elucidates the development of photoaffinity probes for the target identification of PD 404182. By the photolabeling experiment of HIV-1-infected H9 cells using these probes, the author detected proteins specifically bound to PD 404182. These new anti-HIV agents may be promising agents for anti-HIV therapy because their mechanisms of action differ from those of the currently approved anti-HIV agents.

Department of ChemistryUniversity of Massachusetts Amherst, USAPh. D. in Pharmaceutical Sciences Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

Introduction.- Development of Divergent Synthetic Methods of Pyrimidobenzothiazine and Related Tricyclic Heterocycles.- Structure-Activity Relationship Study of PD 404182 Derivatives for the Highly Potent Anti-HIV Agents.- Design and Synthesis of Photoaffinity Probes and their Application to Target Identification Study of PD 404182.- Conclusions.

Erscheint lt. Verlag 7.10.2013
Reihe/Serie Springer Theses
Springer Theses
Zusatzinfo XI, 151 p. 98 illus., 3 illus. in color.
Verlagsort Tokyo
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Chemie Organische Chemie
Technik
Schlagworte Anti-HIV Agents • Aromatic Nucleophilic Substitution • C-H Functionalization • C?H Functionalization • C−H Functionalization • PD 404182 • Photoaffinity Labeling • Pyrimidobenzothiazine • Structure-activity Relationship • Structure?activity Relationship • Structure−activity Relationship
ISBN-10 4-431-54445-3 / 4431544453
ISBN-13 978-4-431-54445-6 / 9784431544456
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