Chemistry of Bioconjugates (eBook)

RAVIN NARAIN, PhD, is Associate Professor in the Department of Chemical and Materials Engineering at the University of Alberta. He has published more than 100 articles in peer-reviewed journals and is the editor of Engineered Carbohydrate-Based Materials for Biomedical Applications (Wiley). Dr. Narain's research examines nanomedicine and regenerative medicine, with an emphasis on developing new biomaterials for gene delivery and tissue engineering.

PREFACE vii

CONTRIBUTORS ix

SECTION I GENERAL METHODS OF BIOCONJUGATION

1 Covalent and Noncovalent Bioconjugation Strategies 3

Rajesh Sunasee and Ravin Narain

SECTION II POLYMER BIOCONJUGATES

2 Bioconjugates Based on Poly(Ethylene Glycol)s and
Polyglycerols 79

Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul-Haq, and
Jayachandran N. Kizhakkedathu

3 Synthetic Polymer Bioconjugate Systems 104

Marya Ahmed and Ravin Narain

4 Natural Polymer Bioconjugate Systems 133

Lichao Liu, Xiuwei Pan, and Weian Zhang

5 Dendrimer Bioconjugates: Synthesis and Applications 146

Ali Nazemi and Elizabeth R. Gillies

SECTION III ORGANIC NANOPARTICLES BASED BIOCONJUGATES

6 Bioconjugation Strategies: Lipids, Liposomes, Polymersomes,
and Microbubbles 187

Anirban Sen Gupta and Horst A. von Recum

7 Organic Nanoparticle Bioconjugate: Micelles, Cross-Linked
Micelles, and Nanogels 203

Maria Vamvakaki

8 Carbon Nanotubes and Fullerene C60 Bioconjugates 239

Keshwaree Babooram and Ravin Narain

SECTION IV INORGANIC NANOMATERIALS BIOCONJUGATES (METALS,
METAL OXIDES--QUANTUM DOTS, IRON-OXIDE)

9 Gold Nanomaterials Bioconjugates 257

Qian Yang

10 Methods for Magnetic Nanoparticle Synthesis and
Functionalization 281

Mohammad H. El-Dakdouki, Kheireddine El-Boubbou, Jingguang Xia,
Herbert Kavunja, and Xuefei Huang

11 Quantum Dots Bioconjugates 315

Xiaoze Jiang, Meifang Zhu, and Ravin Narain

12 Silica Nanoparticle Bioconjugates 327

Yohei Kotsuchibashi, Mitsuhiro Ebara, and Ravin Narain

13 Polyhedral Oligomeric Silsesquioxanes (POSS) Bioconjugates
344

Weian Zhang, Zhenghe Zhang, and Lizhi Hong

SECTION V CELL-BASED, HYDROGELS/MICROGELS AND
GLYCO-BIOCONJUGATES

14 Cell-Based Bioconjugates 357

Mitsuhiro Ebara

15 Bioresponsive Hydrogels and Microgels 370

Xue Li and Michael J. Serpe

16 Conjugation Strategies Used for the Preparation of
Carbohydrate-Conjugate Vaccines 387

Rachel Hevey and Chang-Chun Ling

SECTION VI CHARACTERIZATION, PHYSICO-(BIO)CHEMICAL
PROPERTIES, AND APPLICATIONS OF BIOCONJUGATES

17 Properties and Characterization of Bioconjugates 417

Ali Faghihnejad, Jun Huang, and Hongbo Zeng

18 Physico-Chemical and Biochemical Properties of Bioconjugates
431

Marya Ahmed and Ravin Narain

19 Applications of Bioconjugates 444

Marya Ahmed and Ravin Narain

INDEX 457