Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Multifarious Determinants of Cytokine Receptor Signaling Specificity
Ignacio Moraga, Jamie Spangler, Juan Mendoza and K. Christopher Garcia
Pathogenic Mechanisms of Bradykinin Mediated Diseases: Dysregulation of an Innate Inflammatory Pathway
Allen P. Kaplan and Kusumam Joseph
The Role of Short-Chain Fatty Acids in Health and Disease
Jian Tan, Craig McKenzie, Maria Potamitis, Alison N. Thorburn, Charles R. Mackay and Laurence Macia
Combined Immunodeficiencies with Non-Functional T Lymphocytes
Luigi D. Notarangelo
The CD200-CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host-Pathogen Interactions
Christine A. Vaine and Roy J. Soberman
Immunopathogenesis of Neuromyelitis Optica
Michael Levy, Benjamine Arellano,  Brigitte Wildemann,  Sven Jarius, Saranya Sasidharan, Martin Weber and Olaf Stuve