Nucleic Acid Therapeutics in Cancer
Humana Press Inc. (Verlag)
978-1-4684-9858-5 (ISBN)
I. Introduction and Perspective.- 1 Antisense Methodology: An Assessment After 25 Years.- 2 Nucleic Acid Therapeutics: An Introduction.- II. Basic Methodology.- 3 Targeted Genome Modification Via Triple Helix Formation.- 4 Therapeutic Applications of Ribozymes.- 5 Use of Catalytic DNA in Target Validation and Therapeutics.- 6 Targeted Destruction of Small, Stable RNAs: Principles Applicable to Antisense Therapies.- 7 Mechanism of Action of Antisense RNA in Eukaryotic Cells.- III. Delivery.- 8 The Transport of Oligonucleotides Into Cells.- 9 Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Material.- 10 Molecular Vectors for Gene Delivery to Cancer Cells.- IV. Targeting.- 11 Considerations on the Design of Antisense Oligonucleotides.- 12 Identification of Hybridization Accessible Sequence in Messenger RNA.- V. Clinical Targets.- 13 Nucleic Acids As Gene Targeting Therapeutics.- 14 LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen): Phosphorothioate Antisense Oligonucleotides With Pleiotropic Mechanisms of Action.- 15 Antisense Protein Kinase A-RI? Restores Normal Signal Transduction Signatures to Inhibit Tumor Growth.
Reihe/Serie | Cancer Drug Discovery and Development |
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Zusatzinfo | 5 Illustrations, color; 44 Illustrations, black and white; X, 221 p. 49 illus., 5 illus. in color. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 152 x 229 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
ISBN-10 | 1-4684-9858-4 / 1468498584 |
ISBN-13 | 978-1-4684-9858-5 / 9781468498585 |
Zustand | Neuware |
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