Diagnosis and Management of Melanoma in Clinical Practice

1 Epidemiology of Malignant Meloma.- Complexity and Dissonance.- Recall Bias.- Exposure.- Sex and Prognosis.- Age and the Neoplastic Process.- Rising Incidence Rates.- Rising Population Death Rates.- The Ozone Layer.- Prognosis as Function of Incidence.- Conclusion.- 2 Clinical Differential Diagnosis of Cutaneous Malignant Melanoma.- Patients at Risk of Developing Melanoma.- Lentigo Maligna Melanoma.- Superficial Spreading Malignant Melanoma.- Nodular Melanoma.- Acral or Acral Lentiginous Melanoma.- Aids to Clinical Diagnosis.- 3 Differential Diagnosis of Malignant Melanoma by Algorithm.- Freckles (Ephelides).- Seborrhoeic Warts.- Lentigo.- Lentigo Maligna (Hutchinson’s Freckle).- Junctional Naevus.- Superficial Spreading Malignant Melanoma.- Café au Lait Patch.- Plane Warts.- Skin Tags.- Dermatofibroma (Histiocytoma).- Seborrhoeic Wart (Basal Cell Papilloma).- Compound Naevus.- Nodular Malignant Melanoma.- Pigmented Basal Cell Carcinoma.- Blue Naevus.- Giant Comedone.- Solar Keratoses.- Bowen’s Disease.- Squamous Cell Carcinoma.- Basal Cell Carcinoma (Rodent Ulcer).- Irritated Seborrhoeic Wart.- Pyogenic Granuloma.- Spitz Naevus.- Campbell de Morgan Spot (Cherry Angioma).- Haemangioma.- 4 Clinical Diagnosis of Melanoma.- The Patient’s History.- Types of Malignant Melanoma and Presenting Features.- Accuracy in Diagnosis.- Aids to Clinical Diagnosis.- Image Analysis.- 5 Familial Melanoma.- Genetics.- Estimates of Risk of Melanoma.- Management of AMS Patients.- Non-melanoma Malignancy in the AMS Families.- Conclusions.- 6 The Histological Diagnosis of Cutaneous Melanoma.- Clinical Data.- Diagnostic Specimen.- Histological Features.- Melanoma.- Melanoma in Childhood.- Cutaneous Metastasis Versus (Second) Primary Melanoma.- Prognosis of Melanoma.- Routine DiagnosticPathology Report of Melanoma.- 7 Histopathological Differential Diagnosis.- Benign Melanocytic Lesions with Histological Characteristics Normally Associated with Malignant Melanoma.- Dysplastic Naevi.- Conclusions.- 8 Prognostie Factors in Melanoma.- Localized Melanoma (Stage I).- Regional Nodal Melanoma (Stage IIIa).- Disseminated Melanoma (Stage IV).- 9 Surgery for Malignant Melanoma.- Diagnostic Surgery.- Definitive Primary Treatment.- Later Aesthetic Plastic Surgery.- Curative Surgery for Metastases.- Palliative Surgery.- 10 Isolated Limb Perfusion.- Techniques of Isolated Limb Perfusion.- Indications for Isolated Limb Perfusion.- Results of Therapeutic Isolated Limb Perfusion.- Prophylactic Isolated Limb Perfusion.- Conclusions.- 11 Systemic Treatment of Metastatic Malignant Melanoma.- Single Agent Regimes.- Combination Regimes.- Dose Intensification.- Biological Therapy.- Conclusion.- 12 Progress and Prospects for Therapeutic Targeting Strategies for Disseminated Melanoma.- Introduction: The Problem of Disseminated Melanoma.- Possible Targeting Strategies.- Experimental Targeted Antimelanoma Therapy.- Conclusion.- 13 Psychological Aspects of Malignant Melanoma.- Psychosocial Problems.- Inadequacy of Information.- Treatment of Side Effects.- Psychiatric Morbidity.- Personality and Malignant Melanoma.- Psychological Aftercare.