Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia

Molecular and Cellular Mechanisms.- Disturbance of Endoplasmic Reticulum Functions: A Key Mechanism Underlying Cell Damage ?.- Role and Mechanisms of Secondary Mitochondrial Failure.- Initiating Mechanisms Involved in the Pathobiology of Traumatically Induced Axonal Injury and Interventions Targeted at Blunting Their Progression.- Molecular Signals for Glial Activation: Pro- and Anti-Inflammatory Cytokines in the Injured Brain.- Mechanical and Excitotoxic Lesion of Motoneurons: Effects of Neurotrophins and Ciliary Neurotrophic Factor on Survival and Regeneration.- News from Cerebral Ischemia.- Modelling of the Ischemic Penumbra.- The Acute Ischemic Penumbra: Topography, Life Span, and Therapeutic Response.- Environmental Influence on Gene Expression and Recovery from Cerebral Ischemia.- Neuroprotective Strategies in Nature - Novel Clues for the Treatment of Stroke and Trauma.- Glial Cell Swelling - Effect of Hypothermia.- The Clot Thickens - Thrombolysis and Combination Therapies.- Assessment of Brain Tissue Viability Under Clinical Circumstances.- Heparin-Mediated Extracorporeal LDL/Fibrinogen Precipitation - H.E.L.P. - In Coronary and Cerebral Ischemia.- Remaining Problems in Severe Head Injury.- Pediatric Head Injury: What is Unique and Different.- Apolipoprotein E and the Response of the Brain to Injury.- System Analysis of Patient Management During the Pre- and Early Clinical Phase in Severe Head Injury.- The Frequency, Antecedent Events, and Causal Relationships of Neurologic Worsening Following Severe Head Injury.- Neuroprotective Effects of Riluzole in Neurotrauma Models: A Review.- Challenges in Translating the Efficacy of Neuroprotective Agents in Experimental Models Into Knowledge of Clinical Benefits in Head Injured Patients.- Author Index.- Indexof Keywords.