Hemostasis and Thrombosis – Practical Guidelines in Clinical Management

Dr Hussain Saba, James A. Haley Veterans Hospital, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA. Dr Harold Roberts, School of Medicine, Division of Hematology Oncology, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA.

Contributors, vii Preface, x Acknowledgments, xi 1 Theories of Blood Coagulation: Basic Concepts and Recent Updates, 1 Dougald M. Monroe and Maureane Hoffman 2 Vascular Endothelium, Infl uence on Hemostasis: Past and Present, 14 Hussain I. Saba and Sabiha R. Saba 3 Coagulation Testing: Basic and Advanced Clinical Laboratory Tests, 30 Nils Egberg and Margareta Blomback 4 Factor VIII Defi ciency or Hemophilia A: Clinical Bleeding and Management, 45 Pier Mannuccio Mannucci and Massimo Franchini 5 Factor IX Defi ciency or Hemophilia B: Clinical Manifestations and Management, 57 Raj S. Kasthuri, Harold R. Roberts, and Paul E. Monahan 6 Factor XI Deficiency or Hemophilia C, 71 Charles E. Bane, Anne T. Neff, and David Gailani 7 Factor VIII and IX Inhibitors in Hemophilia, 82 Meera Chitlur and Jeanne Lusher 8 Treatment Options for Acquired Hemophilia, 93 Anjali Sharathkumar and David Green 9 Factor XII Deficiency or Hageman Factor Deficiency, 112 Evi X. Stavrou and Alvin H. Schmaier 10 Inherited Combined Factor Deficiency States, 127 Asma Latif and Louis Aledort 11 Acute and Chronic Immune Thrombocytopenia: Biology, Diagnosis, and Management, 137 Samir Dalia and Benjamin Djulbegovic 12 Disseminated Intravascular Coagulation: Diagnosis and Management, 151 Stephanie J. Davis and Craig M. Kessler 13 Mechanisms of Fibrinolysis and Basic Principles of Management, 169 John W. Weisel and Rustem I. Litvinov 14 Post-thrombotic Syndrome, 186 Jean-Philippe Galanaud and Susan R. Kahn 15 Von Willebrand Disease: Clinical Aspects and Practical Management, 197 Francesco Rodeghiero, Alberto Tosetto, and Giancarlo Castaman 16 Platelets in Hemostasis: Inherited and Acquired Qualitative Disorders, 209 Noman Ashraf and Hussain I. Saba 17 Contributions of Platelet Polyphosphate to Hemostasis and Thrombosis, 236 James H. Morrissey 18 Thrombotic Microangiopathy: Biology, Diagnosis, and Management, 246 Samir Dalia and Hussain I. Saba 19 Hemostasis and Aging, 259 Lodovico Balducci 20 Hemostatic Problems in Chronic and Acute Liver Disease, 271 Ton Lisman and Robert J. Porte 21 Cancer and Thrombosis, 284 Erica A. Peterson and Agnes Y. Y. Lee 22 An Update on Low-Molecular-Weight Heparins, 296 Jawed Fareed, Debra Hoppensteadt, and Walter P. Jeske Index, 315 Color plate section can be found facing page 212