Hemoglobin and Red Cell Structure and Function

I. Hemoglobin Structure and Function.- Structure of Haemoglobin M Milwaukee, a Mutant Form Exhibiting Interaction between Ferrous and Ferric Subunits.- The Interaction Between Hemoglobin and Its “Oxygen-Linked” Ligands.- The Interaction of Sickle Hemoglobin with DPG, CO2, and with Other Hemoglobins: Formation of Asymmetrical Hybrids.- Enhancement of the Acid and Alkaline Bohr Effects of Hemoglobin by Organic Phosphates.- Functional Non-Equivalence of ? and ? Hemes in Human Hemoglobins.- II. Red- Cell Metabolism and Function.- Hemoglobin Casper G8 ? 106 Leu?Pro: Further Evidence that Hemoglobin Mutations are Not Random.- Potential Effects of Hemoglobin Concentration on Red Cell Metabolism Together with Observations on Red Cell Metabolic Differences Between Men and Women.- Catalase Activity and Red Cell Metabolism.- Red Cell Hexosemonophosphate Shunt Deficiency in Uremia.- Effect of Inorganic Phosphate on Red Cell Metabolism: In Vitro and In Vivo Studies.- Studies of the Metabolic Basis of the ATP-DPG Differences in Genetically Selected High and Low ATP-DPG Rat Strains.- III. Carbonic Anhydrase and Carbon Dioxide Transport.- Introductory Remarks at the Beginning of Session III 167.- Functional Aspects of the Three-Dimensional Structure of the Active Site of Carbonic Anhydrase.- The Effect of Temperature on the Catalytic Activity of Bovine Carbonic Anhydrase.- Carbonic Anhydrase, Red Cell Membranes, and CO2 Transport.- Effect of Chlorthalidone Binding on the Electrophoretic Properties of Human Red Cell Carbonic Anhydrase Isozymes.- The Role of Carbonic Anhydrase in the Control of Intracellular pH.- The Contribution of Carbamate in Human Adult and Foetal Blood to the CO2 Exchange during the Respiratory Cycle.- IV. Sickle Cell Structure and Function.- IntroductoryRemarks at the Beginning of Session IV.- Thermal (or Endothermic) Aggregation of Sickle Cell Hemoglobin (Hb S) During Sickling.- Chemical and Biological Aspects of the Inhibition of Red Blood Cell Sickling by Cyanate.- Preliminary Clinical Trials with Cyanate.- Carbamyl Phosphate Modification of Hemoglobin S Structure Resulting in Altered Sickling.- Oxygen Affinity Independent Action of Cyanate and 2,3 DPG on Sickling.- Evaluation of Oral Urea in the Management of Sickle Cell Anemia.- The Sickling Phenomenon of Deer Erythrocytes.- Further Studies on the Antenatal Detection of Sickle Cell Anemia and Other Hemoglobinopathies.- V. Adaptation to Hypoxia.- Adjustments of the Oxygen Transport System During Residence at High Altitude.- Red Cell Metabolism and Oxygen Affinity of Healthy Individuals during Exposure to High Altitude.- Enzymatic Mechanisms of Red Cell Adaptation to Anemia 377.- Red Cell Metabolic Changes in Acute and Chronic Exposure to High Altitude.- Effects of Cyanate in Rabbits.- VI. The Effect of Oxygen Affinity on Oxygen Transport: Blood Storage.- Studies on the Ability of Stored Blood to Transport Oxygen In Vivo.- The Two Bohr Effects: Physiological Consequences of Ligand Interaction with Hemoglobin.- Rejuvenation and Freezing of Outdated Human Red Cells.- Effects of Adenine on Stored Human Red Cells.- Hemoglobin Function During Blood Storage XV: Effects of Metabolic Additives Inosine and Methylene Blue on p50 and 2,3-DPG.- The Effect of Massive Transfusion of Stored Blood on Oxygen Transport - A Preliminary Report.