Cerebral Blood Flow in Acute Head Injury

1. Measurement and Cerebral Blood Flow (CBF) and Oxygen Consumption, and the Regulation of Cerebral Circulation.- Experimental Studies of Cerebral Blood Flow.- Measurement of Cerebral Blood Flow (Human Studies).- Human Studies of Cerebral Metabolic Rate of Oxygen (CMRO,).- Hypothermia.- CO2 Reactivity and Adaptation to Prolonged Hyperventilation.- The Use of Prolonged Continuous Hyperventilation. Pro et contra.- Cerebral Autoregulation (CA).- 2. Ischaemic Thresholds and Development of Ischaemia.- 3. The Effect of Barbiturate and Mannitol on CBF and Metabolism.- Barbiturate: Experimental Studies.- Human Investigations.- Mannitol.- Mannitol and Blood-Brain Barrier (BBB).- 4. Experimental Studies of Head Injury.- 5. Human Studies of Head Injury.- ICP Recordings in Patients with Head Injury.- Biochemical Studies of CSF.- 6. The Author's Own Studies.- CBF and CMRO2 in the Acute Phase of Head Injury (Own Studies).- Presentation of the Study and the Investigational Methods Used.- Repeated Studies of CBF.- Studies of CMRO2.- Studies of Relationship Between CMRO2 and CBF.- Repeated Studies of Cerebral Autoregulation.- Studies of Cerebral Autoregulation During Two Levels of PaCO2.- Studies of CO2 Reactivity.- Studies of Barbiturate- and CO2 Reactivities.- Summary of the Nine Studies.- Discussion of the Results.- Summary Concerning Dynamic Changes in Cerebral Circulation and Metabolism.- Therapeutic Considerations.- Future Studies of Cerebral Circulation and Metabolism in the Acute Phase of Head Injury.- Summary.- References.