Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

Drug Receptors.- Molecular Studies of Glutamate Receptors.- GABA Receptor Pharmacology.- Serotonin Receptor Subtypes: Exploiting their Therapeutic Potential.- Peptide Receptor Antagonists.- Angiotensin Receptor Subtypes and their Pharmacology.- Foundations and Future of Molecular Pharmacology.- Signal Transduction.- Lipid Messengers and Protein Kinase C for Intracellular Signalling.- Mechanisms for the Regulation of Inositol Lipid Signaling and Calcium Homeostasis.- G-Protein-Linked Receptors and Tyrosine Kinase-Mediated Signal Transduction Pathways: A Mid-1990s Perspective, with Working Hypotheses.- Receptor-G Protein Effector Coupling: Coding and Regulation of the Signal Transduction Process.- Pharmacology of Ion Channels.- Novel Aspects of the Pharmacology of Calcium Channel Modulators.- Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract.- Aspects of Potassium Channel Modulation.- Drug Metabolism.- The Proliferating P450s: Providers of Polysubstrate Pharmacology.- Human Cytochromes P450: Regulation and Functional Variability.- Drug Conjugation: Diversity and Biological Significance.- Interethnic Differences in Drug Metabolism and Pharmacogenetics.- Dietary Effects on Drug Metabolism.- Neuropharmacology.- Neurotransmitter Functions of Mammalian Tachykinins: Substance P and Neurokinin A.- Molecular Events Underlying the Anti-Opioid Effect of Cholecys-tokinin Octapeptide (CCK-8) in the Central Nervous System.- Pharmacology of Excitatory Amino Acid Receptors.- GABA Receptors: Recent Advances.- Therapeutic Possibilities with Serotonergic Drugs.- The Pharmacology of Neurotrophic Factors.- New Perspectives in the Pharmacology of Parenchimal Brain Anoxia-Ischemia.- Pathophysiology and Future Pharmacotherapy of Chronic Pain.- Neurohormonal Systems Underlying Drug Addiction: Relevance for Treatment Strategies.- Molecular and Cellular Mechanisms in Neurosecretion.- Purines.- Role of Purines in the Central Nervous System.- Adenosine: Some Therapeutic Applications and Prospects.- Cardiovascular Pharmacology.- Endothelins: Recent Progress.- Drugs Directly Affecting the Arterial Wall.- Chronic Drug Treatment of Essential Hypertension.- Role of Potassium Channel Blockers in the Treatment of Cardiac Arrhythmias.- Nitric Oxide.- Nitric Oxide in the Cardiovascular System.- Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission.- Endocrine Pharmacology and Immunopharmacology.- Neuroendocrine Hormones and the Immune System.- Selected Aspects of the Immunopharmacology of Cytokines.- Targeted Therapy of Cancer and Autoimmune Diseases.- The Pharmacology of Gene Expression.- Antisense Therapeutics.- Pulmonary Pharmacology.- Molecular Mechanisms of Anti-Asthma Therapy.- Chemotherapy.- Membrane Transport of Anticancer Drugs and Drug Resistance.- Toxicology.- Importance of Individual Enzymes in the Control of Ultimate Carcinogens.- Molecular and Cellular Aspects of Chemical Carcinogenesis.- Alterations in Cell Signaling and Cytotoxicity.- Calcium-Dependent Mechanisms in Drug Toxicity and Cell Killing.- Liver Toxicity Mediated by Leukocytes and Kupffer Cells.- Regulatory Requirements for Drug Registration.- Harmonization of Drug Regulation and Trial Requirements: Clinical Pharmacological Aspects and Responsibilities.- Pharmacological Methods.- In Vivo Magnetic Resonance in Pharmacological Research.- Application of Cell Culture Systems to the Study of Drug Transport and Metabolism.- Instructional Methods.- Providing Quality Education in Pharmacology: The Affordable Options.