Ion Channels

1 Fluorescence Spectroscopy to Probe the Structure and Cellular Dynamics of Ion Channels.- 1. Introduction.- 2. Methods, Principles, and Utility of Fluorescence Spectroscopy.- 3. Selection, Design, and Utilization of Ion Channel Probes.- 4. Fluorescence Spectroscopy of the Voltage-Dependent Na + Channel.- 5. Cellular Mapping of Na+ Channels in Excitable Tissues.- 6. Conclusion.- 7. References.- 2 M Currents.- 1. Prologue.- 2. M Current.- 3. M-Current Kinetics.- 4. Physiological Function.- 5. Pharmacology of M Current.- 6. Synaptic Inhibition of M Current.- 7. Future Work.- 8. References.- 3 Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes.- 1. Introduction.- 2. Voltage and Patch Clamping.- 3. Impact of Neurotoxins in Molecular Pharmacology.- 4. The Histrionicotoxins.- 5. Summary.- 6. References.- 4 Developmental Changes in Acetylcholine Receptor Channel Properties of Vertebrate Skeletal Muscle.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Postscript.- 6. References.- 5 Intracellular ATP and Cardiac Membrane Currents.- 1. Introduction.- 2. Techniques for the Single Cardiac Cell.- 3. Whole-Cell Current and Intracellular ATP Level.- 4. ATP-Sensitive K Channel.- 5. Effects of ATP on Other K Channels.- 6. Conclusion.- 7. References.- 6 Calcium Antagonist Receptors.- 1. Introduction.- 2. Radioreceptor Binding Studies.- 3. Atypical Actions of Calcium Antagonists.- 4. The Relation of Calcium Antagonist Receptors to Voltage-Sensitive Calcium Channels.- 5. Future Developments in Calcium Antagonist Receptors.- 6. References.- 7 The Amiloride-Blockable Sodium Channel of Epithelial Tissue.- 1. Introduction.- 2. Na+ Uptake at the Apical Membrane.- 3. A6 Cells as a Model for Kidney Distal Tubule.- 4. Single Na + Channel Activity.- 5. A Model for the Regulation of Apical Na+ Permeability.- 6. Future Work.- 7. References.- 8 Ionic Channels in Ocular Epithelia.- 1. Introduction.- 2. Low-Noise Methods and Glass Considerations.- 3. General Approach to Channel Identification.- 4. Selectivity.- 5. Current-Voltage Relations.- 6. Kinetics of Gating.- 7. Characterization of Blockers.- 8. Channel Types Observed in Ocular Epithelia.- 9. References.