Concepts in Viral Pathogenesis

Host Control of Viral Spread.- Early Non-immune Control.- 1. Interferon and Viral Pathogenesis.- 2. Natural Killer Cells in Viral Infection.- 3. The Role of the Complement System in Host Defense Against Virus Diseases.- 4. Proteolytic Cleavage and Virus Pathogenesis.- Immune Control—Humoral.- 5. Mechanisms of Virus Neutralization.- 6. Antibody-and Complement-Dependent Lysis of Virus-Infected Cells.- Immune Control—Cellular.- 7. The Inflammatory Response to Acute Viral Infections.- 8. MHC Restriction and Cytotoxic T Lymphocytes.- 9. Antibody-Dependent Cellular Cytotoxicity (ADCC) Mediated by Human Killer Lymphocytes (K-Cells).- 10. Cloning of Functional T Lymphocytes.- Genetic Control.- 11. Host Genes that Influence Susceptibility to Viral Diseases.- 12. Host Genes Controlling the Immune Response.- 13. On the Role of Recombinant Retroviruses in Murine Leukemia.- Host Range and Tissue Tropism.- 14. Viral Receptors: Expression, Regulation and Relationship to Infectivity.- 15. Viral Genes and Tissue Tropism.- 16. Utilization of Host Proteins as Virus Receptors.- 17. Host Range and Tissue Tropisms: Antibody-Dependent Mechanisms.- 18. Enveloped Virus Maturation at Restricted Membrane Domains.- 19. Viruses and Differentiation: The Molecular Basis of Viral Tissue Tropisms.- Virus Maturation and Diversity.- 20. Continuum of Change in RNA Virus Genomes.- 21. Reassortment Continuum.- 22. Immune Selection of Virus Variants.- 23. Antigenic Variants of Viruses and Their Relevance to Clinical Disease.- Virus Persistence.- 24. Unique Interactions of Retroviruses with Eukaryotic Cells.- 25. Molecular Biology of Herpes Simplex Virus Latency.- 26. Cellular Oncogenes and Pathogenesis of Cancer.- 27. Antibody Initiates Virus Persistence: Immune Modulation and Measles Virus Infection.-28. Ovarian Infection and Transovarial Transmission of Viruses in Insects.- Virus-Interaction with the Immune System.- 29. Virus-Induced Immune Complex Formation and Disease: Definition, Regulation, Importance.- 30. Virus-Induced Autoimmunity.- 31. The Role of Immunospecific Receptors in Retrovirus-Induced Lymphomagenesis.- 32. Viruses as Regulators of Delayed Hypersensitivity T-Cell and Suppressor T-Cell Function.- 33. Mechanisms and Biological Implications of Virus-Induced Polyclonal B-Cell Activation.- Evolving Concepts in Viral Pathogenesis Illustrated by Selected Animal Models.- 34. Virus-Induced Diabetes Mellitus.- 35. Herpesvirus-Induced Atherosclerosis.- 36. Retrovirus-Induced Arthritis.- 37. Virus-Induced Demyelination.- 38. Virus Can Alter Cell Function Without Causing Cell Pathology: Disordered Function Leads to Imbalance of Homeostasis and Disease.- Evolving Concepts in Viral Pathogenesis Illustrated by Selected Diseases in Humans.- 39. Chronic Leukemia.- 40. Hepatitis B Virus Diseases.- 41. Herpesviruses and Cancer.- 42. Epithelial Cell Interactions of the Epstein-Barr Virus.- 43. Viral Gastroenteritis.- 44. Hemorrhagic Fever Viruses.- 45. Marburg and Ebola Viruses: New Agents on the Frontiers of Virology.- 46. Rabies.- 47. Unconventional Viruses.- Control of Viral Diseases.- 48. Antibodies to Synthetic Peptide Immunogens as Probes for Virus Protein Expression and Function.- 49. Recombinant DNA Vaccines.- 50. Monoclonal Antibodies.- 51. Antiviral Drugs.- 52. The Use of Interferons in the Control of Viral Diseases.- 53. Insect Viruses as Pesticides.