Mitochondrial Biogenesis and Breakdown

Valentin Luzikov (Autor)

Buch | Softcover

362 Seiten

2012 | Softcover reprint of the original 1st ed. 1985
Springer-Verlag New York Inc.
978-1-4684-1652-7 (ISBN)

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It is a strange fact that many modern cell biochemists have a keen interest in biosynthetic processes, such as protein and nucleic biosynthesis or organelle biogenesis, but tend to regard degradative processes merely as irritating reactions that disrupt the flow of synthetic reactions. Historically, the elucidation of catabolic pathways preceded that of anabolic pathways, so that there is also a tendency to regard work on proteases, phospholipases, nucleases, etc., as somewhat "old-fashioned. " It is the great contribution of Professor Luzikov's book to show that, at least in the case of mito- chondrial research, the separation of studies on anabolic and cata- bolic processes has been very harmful. In an extremely erudite and measured way, the author carefully develops the argument that we can only understand mitochondrial biogenesis fully if we take into account the role of degradative processes. The action of lytic enzymes is shown not to be a random affair, but rather a process that is fully integrated into the process of mitochondrial assembly. A second important contribution of this book is the fact that it contains a masterly review of the fundamental literature on mitochon- drial structure, function, breakdown and synthesis presented in an integrated and logical manner.

One Structural Organization of Mitochondria.- 1.1 Partitioning of Mitochondria.- 1.2 Structural Organization of the Outer Mitochondrial Membrane.- 1.3 Structural Organization of the Inner Mitochondrial Membrane.- Two General Manifestations and Molecular Mechanisms of Mitochondrial Degradation.- 2.1 General Manifestations of Mitochondrial Degradation.- 2.2 Molecular Mechanisms of Mitochondrial Degradation.- Three Mechanisms of Mitochondrial Stabilization.- 3.1 Role of Oxidative Phosphorylation in Stabilization of Isolated Mitochondria.- 3.2 Studies on the Molecular Mechanisms of Mitochondrial Stabilization in Model Systems.- 3.3 Protection of Mitochondrial Lipids from Peroxidation.- Four Mitochondrial Degradation in the Cell.- 4.1 Mechanisms of Intracellular Mitochondrial Degradation.- 4.2 Role of Oxidative Phosphorylation in Mitochondrial Survival In Vivo.- Five Topography of the Synthesis of Mitochondrial Proteins.- 5.1 Criteria of the Origin of Mitochondrial Proteins.- 5.2 Topography of the Synthesis of Proteins of Different Mitochondrial Compartments.- 5.3 Relative Contribution of Mitochondrial and Cytoplasmic Translation to Mitochondrial Formation.- Six Mitochondrial Assembly.- 6.1 Some Model Systems Used in Studying Mitochondrial Assembly.- 6.2 Mechanisms of Protein Transport Across Biological Membranes.- 6.3 Protein Transport Across Mitochondrial Membranes.- 6.4 Incorporation of Mitochondrial Translation Products into the Inner Mitochondrial Membrane.- 6.5 Assembly of Enzymic Complexes in the Inner Mitochondrial Membrane.- 6.6 Concluding Remarks.- Seven Reconstitution of the Inner Mitochondrial Membrane and its Fragments.- 7.1 Specific Binding of Individual Protein Components to the Inner Mitochondrial Membrane.- 7.2 Mitochondrial Inner Membrane Fragmentation andReassociation of Fragments.- 7.3 Formation of Energy-Transforming and Transport Systems on the Basis of Phospholipid Vesicles.- 7.4 Reconstitution of Enzymic Complexes of the Inner Mitochondrial Membrane.- Eight Control Over Mitochondrial Assembly.- 8.1 Formation of Abnormalities in the Inner Mitochondrial Membrane and Their Elimination During Respiratory System Development.- 8.2 Membrane-Bound Proteinases of Yeast Mitochondria and Their Possible Involvement in the Regulation of Mitochondrial Formation.- Nine A Broader Look at the Prospects for Further Studies.- Addendum.- References.

Zusatzinfo	XVI, 362 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
ISBN-10	1-4684-1652-9 / 1468416529
ISBN-13	978-1-4684-1652-7 / 9781468416527
Zustand	Neuware