Therapy of Malignant Brain Tumors

1 Pathology of Human Intracranial Neoplasia.- I. Introduction.- II. Basic Principles of Neurooncology.- III. Classification and Grading.- IV. Epidemiology.- V. Special Neurooncology.- References.- 2 Neurosurgery of Malignant Brain Tumors.- I. Introduction and Historical Retrospect.- II. General Neurosurgery.- III. Special Neurosurgery.- IV. Significance of the Surgical Measures and Critical Assessment of Their Results.- References.- 3 Neurosurgical Interventions for Intracranial Metastases.- Data on the Morbidity.- Indications for Operation.- Operative Technique.- Results of Operation.- References.- 4 Stereotactic Biopsy and Technique of Implantation (Instillation) of Radionuclids.- 1. Biopsy for Differentiation of Intracranial Processes and Optimization of Therapy.- 2. Curie (Brachy-Curie) Therapy (BCiT).- 3. Techniques of Implantation of Radionuclides.- 4. Results of BCiT.- 5. New Results of BCiT.- 6. The Place of BCiT in the Treatment Plan.- 7. Indications for Curie (Brachy-Curie) Therapy and Combined Radiotherapy.- References.- 5 Radiation Therapy of Brain Tumors.- 1. Introduction.- 2. Fundamentals of Radiotherapy.- 3. Radiotherapeutic Technique.- 4. Special Radiotherapy of Brain Tumors.- 5. Complications of Radiotherapy.- References.- 6 Principles of Chemotherapy in Brain Neoplasia.- I. Introduction.- II. Basic Principles.- III. Specific Therapeutic Agents.- IV. Practical Pharmacologic Considerations.- V. Histopathologic Effects of Brain Tumor Chemotherapy.- VI. Modes of Drug Administration.- VII. Blood-Brain Barrier Disruption (BBBD).- VIII. Drug Rescue Techniques.- IX. Radiation Sensitizers.- X. Monoclonal Antibodies.- XI. Special Cases in CNS Tumor Therapy.- XII. Experimental Drugs.- XIII. Drug Protocols.- XIV. Conclusion.- References.- 7 Results of Chemotherapyof Malignant Brain Tumors in Adults.- 1. Diagnostics.- 2. Results and Indications of Chemotherapy.- 3. Summary and Conclusions.- References.- 8 Malignant Brain Tumors in Children.- Clinical Features.- Symptoms and Signs of Supratentorial Tumors.- Symptoms and Signs of Infratentorial Tumors.- Diagnostic Tests.- Neuroradiological Investigations.- Principles of Pediatric Neurooncology.- Evaluation of Therapeutic Results.- The Blood-Brain Barrier (BBB).- Iatrogenic BBB Disruption.- Treatment of Brain Tumors by Interferon.- Cytostatic Drugs.- Side-Effects of Combined Therapy.- Special Pediatric Neurooncology.- Clinical Remarks on Tumors of the Pineal Region.- References.