Annual Review of Gerontology and Geriatrics, Volume 34, 2014

Richard L. Sprott, PhD, is Executive Director of the Ellison Medical Foundation. He began his undergraduate studies at Franklin and Marshall College and completed them at the University of North Carolina at Chapel Hill, earning a BA with honours in Psychology. After receiving his PhD in Experimental Psychology (Behavior Genetics) at UNC he went on to a postdoctoral fellowship in Behavior Genetics at the Jackson Laboratory in Bar Harbor, Maine. Following two years of teaching at Oakland University, Dr. Sprott returned to The Jackson Laboratory where he conducted a research programme on single gene influences on behaviour and the interaction of ageing variables with those genes. After a decade in Maine, Dr. Sprott moved to the National Institute on Aging where he directed the Institute's programmes on the Biology of Aging. A major focus of his career has been the development of animal models for ageing research. He developed a nationwide research programme on biomarkers of ageing and the effects of dietary restriction on longevity. He is the author of a large number of books and articles. He is an internationally recognised expert on animal model development and plays an active role in model development in countries around the world. He is the Past President of the International Biogerontological Resource Institute (IBRI) in Friuli, Italy. Dr. Sprott left the National Institute on Aging in 1998 to become the first Executive Director of the Ellison Medical Foundation, created to support basic biological and biomedical research on ageing, and recently expanded to provide similar support for basic research on infectious diseases of importance in the developed and developing worlds. The Ellison Medical Foundation is the largest private foundation source of funding for the biology of ageing, providing about $28,000,000 per year in grant funds for ageing research and $12,000,000 for infectious disease research.

Preface









1. Longevity pathways in mammalian stem cells




Anne Brunet, Salah Mahmoudi, Elena Mancini, Victoria A. Rafalski, and Ashley E. Webb




2. Essential Genes and Lifespan




Sean P. Curran




3. Oxygen and Aging




Jason N. Pitt, Scott F. Leiser, and M. Kaeberlein




4. Aging, Disease and Longevity in Mice




David B. Lombard and Richard A. Miller




5. Primate Models for Human Brain Aging and Neurological Diseases




Caleb Finch and Steve Austad




6. Genes for Exceptional Longevity




Nir Barzilai and Gil Atzmon




7. Etiology of Individual Differences in Human Health and Longevity




Deborah Finkel, Lotte Gerritsen, Chandra A. Reynolds, Anna K. Dahl, and Nancy L. Pedersen




8 Exploiting causal complexity in aging




Gerald E. McClearn, David J. Vandenbergh, J. Tobias Stout, and Roger J. McCarter




9. Networks in the Biology of Aging: Powerful tools for a complex process




Mark A. McCormick and Daniel E. L. Promislow




10. Nature, Nurture & Chance: Their Roles in Interspecific & Intraspecific Modulations of Aging




George M. Martin