Analgesic and NSAID-induced Kidney Disease

The first in the "Oxford Monographs on Clinical Nephrology" series, this book covers the aetiology and clinical manifestations of classical analgesic nephropathy, and pathologies caused by the newer non-steroidal anti-inflammatory drugs

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Analgesic nephropathy, first recognized in 1950, was for two decades the most common cause of both acute and chronic renal failure in some parts of the world. This comprehensive text follows the story of the disease from its early description to its ultimatly sucessful prevention. The aetiology, pathology, diagnosis, and treatment are described by those who have played leading roles in elucidating the nature of the disease, and in persuading society to take effective measures to prevent its occurence. The second section describes those renal disorders resulting from the use of newer non-steroidal anti-inflammatory drugs and paracetamol - disorders which are rising in frequency and may prove more difficult to prevent. Finally, the book considers the urothelia cancers caused by phanacetin-containing headache powders, a late outcome of analgesic abuse. With contributions from a distinguished international group of authors, this is a unique book on a challenging problem. Throughout the text, theory and practice are integrated, and attention is drawn to the valuable lessons gained from the study of the analgesic nephropathies.