COX-2 Inhibitors

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effect. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. Animal models and clinical information are presented. The book addresses clinicians interested in the latest information about this class of drugs, researchers and students in t

The discovery of COX-2.- Structural diversity of selective COX-2 inhibitors.- The molecular and biological basis for COX-2 selectivity.- Pharmacology and toxicology of COX-2 inhibitors.- Efficacy and gastrointestinal safety of selective COX-2 inhibitors.- Role of COX-2 in ulcers and ulcer healing.- COX-2 and the cardiovascular system.- Effects on the kidney: role of COX-2 inhibitors.- Effects on the lungs: role of COX-2 inhibitors.- Reproduction: role of COX-2 and its inhibition.- COX-2 in cancer.